skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Separation system with a sheath-flow supported electrochemical detector

Patent ·
OSTI ID:985190

An electrochemical detector including side channels associated with a separation channel of a sample component separation apparatus is provided. The side channels of the detector, in one configuration, provide a sheath-flow for an analyte exiting the separation channel which directs the analyte to the electrically developed electrochemical detector.

Research Organization:
Univ. of California (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
FG03-91ER61125
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Number(s):
7,438,792
Application Number:
11/107,295
OSTI ID:
985190
Country of Publication:
United States
Language:
English

References (33)

Synthesis of the First Ferrocene-Labeled Dideoxynucleotide and Its Use for 3‘-Redox End-Labeling of 5‘-Modified Single-Stranded Oligonucleotides journal May 2001
Capillary Electrophoresis Chips with Integrated Electrochemical Detection journal February 1998
Micromachined Separation Chips with a Precolumn Reactor and End-Column Electrochemical Detector journal December 2000
Electrochemical Detection in Polymer Microchannels journal October 1999
Electrophoresis with electrochemical detection in a polymer microdevice journal September 2000
A Single Base Extension Technique for the Analysis of Known Mutations Utilizing Capillary Gel Electrophoreisis with Electrochemical Detection journal July 2002
Amperometric and voltammetric detection for capillary electrophoresis journal November 2002
Lab-on-a-Chip: A Revolution in Biological and Medical Sciences. journal May 2000
Electronic Detection of Single-Base Mismatches in DNA with Ferrocene-Modified Probes journal November 2001
A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis journal August 1996
SBE-TAGS: An array-based method for efficient single-nucleotide polymorphism genotyping journal October 2000
Toward Electrochemical Resolution of Two Genes on One Electrode:  Using 7-Deaza Analogues of Guanine and Adenine To Prepare PCR Products with Differential Redox Activity journal January 2002
Dual-Electrode Electrochemical Detection for Poly(dimethylsiloxane)-Fabricated Capillary Electrophoresis Microchips journal July 2000
Elimination of High-Voltage Field Effects in End Column Electrochemical Detection in Capillary Electrophoresis by Use of On-Chip Microband Electrodes journal April 2001
Voltammetry on Microfluidic Chip Platforms journal November 2000
Micro Total Analysis Systems. 1. Introduction, Theory, and Technology journal June 2002
Microchip Bioprocessor for Integrated Nanovolume Sample Purification and DNA Sequencing journal October 2002
Miniaturized total chemical analysis systems: A novel concept for chemical sensing journal January 1990
Capillary Electrophoresis Chips with a Sheath-Flow Supported Electrochemical Detection System journal July 2004
End-Column Amperometric Detection in Capillary Electrophoresis:  Influence of Separation-Related Parameters on the Observed Half-Wave Potential for Dopamine and Catechol journal February 1999
Integrated Electrophoresis Chips/Amperometric Detection with Sputtered Gold Working Electrodes journal September 1999
Recent developments in detection methods for microfabricated analytical devices journal January 2001
A two-electrode configuration for simplified amperometric detection in a microfabricated electrophoretic separation device journal January 2001
Single-Molecule Detection of DNA Separations in Microfabricated Capillary Electrophoresis Chips Employing Focused Molecular Streams journal November 1999
Electroosmotic pumping and electrophoretic separations for miniaturized chemical analysis systems journal December 1994
Continuous Separations with Microfabricated Electrophoresis−Electrochemical Array Detection journal January 1996
Capillary Gel Electrophoresis with Sinusoidal Voltammetric Detection:  A Strategy To Allow Four-“Color” DNA Sequencing journal October 2001
Fully integrated PCR-capillary electrophoresis microsystem for DNA analysis journal January 2001
Electrochemically Active DNA Probes: Detection of Target DNA Sequences at Femtomole Level by High-Performance Liquid Chromatography with Electrochemical Detection journal May 1994
Fully Integrated On-Chip Electrochemical Detection for Capillary Electrophoresis in a Microfabricated Device journal August 2002
Micro Total Analysis Systems. 2. Analytical Standard Operations and Applications journal June 2002
In-Channel Electrochemical Detection for Microchip Capillary Electrophoresis Using an Electrically Isolated Potentiostat journal March 2002
Palladium Film Decoupler for Amperometric Detection in Electrophoresis Chips journal February 2001