The CCL3L1-CCR5 genotype influences the development of AIDS, but not HIV susceptibility or the response to HAART
- Los Alamos National Laboratory
- NORTHWESTERN UNIV
- JOHNS HOPKINS UNIV
A selective advantage against infectious diseases such as HIV/AIDS is associated with differences in the genes relevant to immunity and virus replication. The CC chemokine receptor 5 (CCR5), the principal coreceptor for HIV, and its chemokine ligands, including CCL3L1, influences the CD4+ target cells susceptibility to infection. The CCL3L1 gene is in a region of segmental duplication on the q-arm of human chromosome 17. Increased numbers of CCL3L1 gene copies that affect the gene expression phenotype might have substantial protective effects. Here we show that the population-specific CCL3L1 gene copy number and the CCR5 {Delta}32 protein-inactivating deletion that categorizes the CCL3L1-CCR5 genotype do not influence HIV/AIDS susceptibility or the robustness of immune recovery after the initiation of highly active antiretroviral therapy (HAART).
- Research Organization:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC52-06NA25396
- OSTI ID:
- 960867
- Report Number(s):
- LA-UR-08-07711; LA-UR-08-7711; TRN: US201008%%776
- Journal Information:
- Nature Medicine, Journal Name: Nature Medicine
- Country of Publication:
- United States
- Language:
- English
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