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Title: Method of making tapered capillary tips with constant inner diameters

Patent ·
OSTI ID:960208
 [1];  [2];  [3];  [3]
  1. West Richland, WA
  2. Kennewick, WA
  3. Richland, WA
+ Show Author Affiliations

Methods of forming electrospray ionization emitter tips are disclosed herein. In one embodiment, an end portion of a capillary tube can be immersed into an etchant, wherein the etchant forms a concave meniscus on the outer surface of the capillary. Variable etching rates in the meniscus can cause an external taper to form. While etching the outer surface of the capillary wall, a fluid can be flowed through the interior of the capillary tube. Etching continues until the immersed portion of the capillary tube is completely etched away.

Research Organization:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC05-76RL01830
Assignee:
Battelle Memorial Institute (Richland, WA)
Patent Number(s):
7,491,341
Application Number:
11/394,840
OSTI ID:
960208
Country of Publication:
United States
Language:
English

References (8)

High-quality near-field optical probes by tube etching journal July 1999
Porous Polymer Monolith Assisted Electrospray journal November 2004
A soft on-column metal coating procedure for robust sheathless electrospray emitters used in capillary electrophoresis-mass spectrometry journal April 2005
High-efficiency peptide analysis on monolithic multimode capillary columns: Pressure-assisted capillary electrochromatography/capillary electrophoresis coupled to UV and electrospray ionization-mass spectrometry journal November 2003
Chemically etched fiber tips for near-field optical microscopy: a process for smoother tips journal January 1998
A Design for Low-Flow Sheathless Electrospray Emitters journal October 1999
Shape control of near-field probes using dynamic meniscus etching journal April 2004
Fabrication Process of Microsurgical Tools for Single-Cell Trapping and Intracytoplasmic Injection journal December 2004

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