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Title: Computational Modeling of Blood Flow in the TrapEase Inferior Vena Cava Filter

Abstract

To evaluate the flow hemodynamics of the TrapEase vena cava filter using three dimensional computational fluid dynamics, including simulated thrombi of multiple shapes, sizes, and trapping positions. The study was performed to identify potential areas of recirculation and stagnation and areas in which trapped thrombi may influence intrafilter thrombosis. Computer models of the TrapEase filter, thrombi (volumes ranging from 0.25mL to 2mL, 3 different shapes), and a 23mm diameter cava were constructed. The hemodynamics of steady-state flow at Reynolds number 600 was examined for the unoccluded and partially occluded filter. Axial velocity contours and wall shear stresses were computed. Flow in the unoccluded TrapEase filter experienced minimal disruption, except near the superior and inferior tips where low velocity flow was observed. For spherical thrombi in the superior trapping position, stagnant and recirculating flow was observed downstream of the thrombus; the volume of stagnant flow and the peak wall shear stress increased monotonically with thrombus volume. For inferiorly trapped spherical thrombi, marked disruption to the flow was observed along the cava wall ipsilateral to the thrombus and in the interior of the filter. Spherically shaped thrombus produced a lower peak wall shear stress than conically shaped thrombus and a larger peakmore » stress than ellipsoidal thrombus. We have designed and constructed a computer model of the flow hemodynamics of the TrapEase IVC filter with varying shapes, sizes, and positions of thrombi. The computer model offers several advantages over in vitro techniques including: improved resolution, ease of evaluating different thrombus sizes and shapes, and easy adaptation for new filter designs and flow parameters. Results from the model also support a previously reported finding from photochromic experiments that suggest the inferior trapping position of the TrapEase IVC filter leads to an intra-filter region of recirculating/stagnant flow with very low shear stress that may be thrombogenic.« less

Authors:
; ;
Publication Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
957185
Report Number(s):
LLNL-JRNL-401016
TRN: US201007%%605
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Journal Article
Journal Name:
Journal of Vascular and Interventional Radiology, vol. 20, no. 6, June 1, 2009, pp. 799-805
Additional Journal Information:
Journal Volume: 20; Journal Issue: 6
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 42 ENGINEERING; BLOOD FLOW; COMPUTERIZED SIMULATION; COMPUTERS; FLUID MECHANICS; IN VITRO; RESOLUTION; REYNOLDS NUMBER; SHEAR; SIMULATION; STAGNATION; STRESSES; THROMBOSIS; TRAPPING; VELOCITY

Citation Formats

Singer, M A, Henshaw, W D, and Wang, S L. Computational Modeling of Blood Flow in the TrapEase Inferior Vena Cava Filter. United States: N. p., 2008. Web.
Singer, M A, Henshaw, W D, & Wang, S L. Computational Modeling of Blood Flow in the TrapEase Inferior Vena Cava Filter. United States.
Singer, M A, Henshaw, W D, and Wang, S L. 2008. "Computational Modeling of Blood Flow in the TrapEase Inferior Vena Cava Filter". United States. https://www.osti.gov/servlets/purl/957185.
@article{osti_957185,
title = {Computational Modeling of Blood Flow in the TrapEase Inferior Vena Cava Filter},
author = {Singer, M A and Henshaw, W D and Wang, S L},
abstractNote = {To evaluate the flow hemodynamics of the TrapEase vena cava filter using three dimensional computational fluid dynamics, including simulated thrombi of multiple shapes, sizes, and trapping positions. The study was performed to identify potential areas of recirculation and stagnation and areas in which trapped thrombi may influence intrafilter thrombosis. Computer models of the TrapEase filter, thrombi (volumes ranging from 0.25mL to 2mL, 3 different shapes), and a 23mm diameter cava were constructed. The hemodynamics of steady-state flow at Reynolds number 600 was examined for the unoccluded and partially occluded filter. Axial velocity contours and wall shear stresses were computed. Flow in the unoccluded TrapEase filter experienced minimal disruption, except near the superior and inferior tips where low velocity flow was observed. For spherical thrombi in the superior trapping position, stagnant and recirculating flow was observed downstream of the thrombus; the volume of stagnant flow and the peak wall shear stress increased monotonically with thrombus volume. For inferiorly trapped spherical thrombi, marked disruption to the flow was observed along the cava wall ipsilateral to the thrombus and in the interior of the filter. Spherically shaped thrombus produced a lower peak wall shear stress than conically shaped thrombus and a larger peak stress than ellipsoidal thrombus. We have designed and constructed a computer model of the flow hemodynamics of the TrapEase IVC filter with varying shapes, sizes, and positions of thrombi. The computer model offers several advantages over in vitro techniques including: improved resolution, ease of evaluating different thrombus sizes and shapes, and easy adaptation for new filter designs and flow parameters. Results from the model also support a previously reported finding from photochromic experiments that suggest the inferior trapping position of the TrapEase IVC filter leads to an intra-filter region of recirculating/stagnant flow with very low shear stress that may be thrombogenic.},
doi = {},
url = {https://www.osti.gov/biblio/957185}, journal = {Journal of Vascular and Interventional Radiology, vol. 20, no. 6, June 1, 2009, pp. 799-805},
number = 6,
volume = 20,
place = {United States},
year = {Mon Feb 04 00:00:00 EST 2008},
month = {Mon Feb 04 00:00:00 EST 2008}
}