skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: A role for cell adhesion in beryllium-mediated lung disease

Abstract

Chronic beryllium disease (CBD) is a debilitating lung disorder in which exposure to the lightweight metal beryllium (Be) causes the accumulation of beryllium-specific CD4+ T cells in the lung and formation of noncaseating pulmonary granulomas. Treatment for CBD patients who exhibit progressive pulmonary decline is limited to systemic corticosteroids, which suppress the severe host inflammatory response. Studies in the past several years have begun to highlight cell-cell adhesion interactions in the development of Be hypersensitivity and CBD. In particular, the high binding affinity between intercellular adhesion molecule 1 (I-CAM1) on lung epithelial cells and the {beta}{sub 2} integrin LFA-1 on migrating lymphocytes and macrophages regulates the concerted rolling of immune cells to sites of inflammation in the lung. In this review, we discuss the evidence that implicates cell adhesion processes in onset of Be disease and the potential of cell adhesion as an intervention point for development of novel therapies.

Authors:
 [1]
  1. Los Alamos National Laboratory
Publication Date:
Research Org.:
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
956679
Report Number(s):
LA-UR-08-08058; LA-UR-08-8058
Journal ID: ISSN 1545-9624; TRN: US201016%%2364
DOE Contract Number:  
AC52-06NA25396
Resource Type:
Journal Article
Journal Name:
Journal of Occupational and Environmental Hygiene
Additional Journal Information:
Journal Volume: 6; Journal Issue: 12; Journal ID: ISSN 1545-9624
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ADHESION; AFFINITY; BERYLLIUM; BERYLLIOSIS; CORTICOSTEROIDS; DISEASES; GRANULOMAS; INFLAMMATION; INTERACTIONS; LUNGS; LYMPHOCYTES; MACROPHAGES; MOLECULES; PATIENTS

Citation Formats

Hong-geller, Elizabeth. A role for cell adhesion in beryllium-mediated lung disease. United States: N. p., 2008. Web. doi:10.1080/15459620903011160.
Hong-geller, Elizabeth. A role for cell adhesion in beryllium-mediated lung disease. United States. https://doi.org/10.1080/15459620903011160
Hong-geller, Elizabeth. 2008. "A role for cell adhesion in beryllium-mediated lung disease". United States. https://doi.org/10.1080/15459620903011160. https://www.osti.gov/servlets/purl/956679.
@article{osti_956679,
title = {A role for cell adhesion in beryllium-mediated lung disease},
author = {Hong-geller, Elizabeth},
abstractNote = {Chronic beryllium disease (CBD) is a debilitating lung disorder in which exposure to the lightweight metal beryllium (Be) causes the accumulation of beryllium-specific CD4+ T cells in the lung and formation of noncaseating pulmonary granulomas. Treatment for CBD patients who exhibit progressive pulmonary decline is limited to systemic corticosteroids, which suppress the severe host inflammatory response. Studies in the past several years have begun to highlight cell-cell adhesion interactions in the development of Be hypersensitivity and CBD. In particular, the high binding affinity between intercellular adhesion molecule 1 (I-CAM1) on lung epithelial cells and the {beta}{sub 2} integrin LFA-1 on migrating lymphocytes and macrophages regulates the concerted rolling of immune cells to sites of inflammation in the lung. In this review, we discuss the evidence that implicates cell adhesion processes in onset of Be disease and the potential of cell adhesion as an intervention point for development of novel therapies.},
doi = {10.1080/15459620903011160},
url = {https://www.osti.gov/biblio/956679}, journal = {Journal of Occupational and Environmental Hygiene},
issn = {1545-9624},
number = 12,
volume = 6,
place = {United States},
year = {Tue Jan 01 00:00:00 EST 2008},
month = {Tue Jan 01 00:00:00 EST 2008}
}