A role for cell adhesion in beryllium-mediated lung disease
Abstract
Chronic beryllium disease (CBD) is a debilitating lung disorder in which exposure to the lightweight metal beryllium (Be) causes the accumulation of beryllium-specific CD4+ T cells in the lung and formation of noncaseating pulmonary granulomas. Treatment for CBD patients who exhibit progressive pulmonary decline is limited to systemic corticosteroids, which suppress the severe host inflammatory response. Studies in the past several years have begun to highlight cell-cell adhesion interactions in the development of Be hypersensitivity and CBD. In particular, the high binding affinity between intercellular adhesion molecule 1 (I-CAM1) on lung epithelial cells and the {beta}{sub 2} integrin LFA-1 on migrating lymphocytes and macrophages regulates the concerted rolling of immune cells to sites of inflammation in the lung. In this review, we discuss the evidence that implicates cell adhesion processes in onset of Be disease and the potential of cell adhesion as an intervention point for development of novel therapies.
- Authors:
-
- Los Alamos National Laboratory
- Publication Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 956679
- Report Number(s):
- LA-UR-08-08058; LA-UR-08-8058
Journal ID: ISSN 1545-9624; TRN: US201016%%2364
- DOE Contract Number:
- AC52-06NA25396
- Resource Type:
- Journal Article
- Journal Name:
- Journal of Occupational and Environmental Hygiene
- Additional Journal Information:
- Journal Volume: 6; Journal Issue: 12; Journal ID: ISSN 1545-9624
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; ADHESION; AFFINITY; BERYLLIUM; BERYLLIOSIS; CORTICOSTEROIDS; DISEASES; GRANULOMAS; INFLAMMATION; INTERACTIONS; LUNGS; LYMPHOCYTES; MACROPHAGES; MOLECULES; PATIENTS
Citation Formats
Hong-geller, Elizabeth. A role for cell adhesion in beryllium-mediated lung disease. United States: N. p., 2008.
Web. doi:10.1080/15459620903011160.
Hong-geller, Elizabeth. A role for cell adhesion in beryllium-mediated lung disease. United States. https://doi.org/10.1080/15459620903011160
Hong-geller, Elizabeth. 2008.
"A role for cell adhesion in beryllium-mediated lung disease". United States. https://doi.org/10.1080/15459620903011160. https://www.osti.gov/servlets/purl/956679.
@article{osti_956679,
title = {A role for cell adhesion in beryllium-mediated lung disease},
author = {Hong-geller, Elizabeth},
abstractNote = {Chronic beryllium disease (CBD) is a debilitating lung disorder in which exposure to the lightweight metal beryllium (Be) causes the accumulation of beryllium-specific CD4+ T cells in the lung and formation of noncaseating pulmonary granulomas. Treatment for CBD patients who exhibit progressive pulmonary decline is limited to systemic corticosteroids, which suppress the severe host inflammatory response. Studies in the past several years have begun to highlight cell-cell adhesion interactions in the development of Be hypersensitivity and CBD. In particular, the high binding affinity between intercellular adhesion molecule 1 (I-CAM1) on lung epithelial cells and the {beta}{sub 2} integrin LFA-1 on migrating lymphocytes and macrophages regulates the concerted rolling of immune cells to sites of inflammation in the lung. In this review, we discuss the evidence that implicates cell adhesion processes in onset of Be disease and the potential of cell adhesion as an intervention point for development of novel therapies.},
doi = {10.1080/15459620903011160},
url = {https://www.osti.gov/biblio/956679},
journal = {Journal of Occupational and Environmental Hygiene},
issn = {1545-9624},
number = 12,
volume = 6,
place = {United States},
year = {Tue Jan 01 00:00:00 EST 2008},
month = {Tue Jan 01 00:00:00 EST 2008}
}