skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Detection of Electrophilic and Nucleophilic Chemical Agents

Abstract

A "real time" method for detecting electrophilic and nucleophilic species generally by employing tunable, precursor sensor materials that mimic the physiological interaction of these agents to form highly florescent berberine-type alkaloids that can be easily and rapidly detected. These novel precursor sensor materials can be tuned for reaction with both electrophilic (chemical species, toxins) and nucleophilic (proteins and other biological molecules) species.

Inventors:
 [1];  [2]
  1. Manteca, CA
  2. Livermore, CA
Publication Date:
Research Org.:
Sandia National Lab. (SNL-CA), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
953735
Patent Number(s):
7,449,579
Application Number:
Assignee:
Sandia Corporation (Livermore, CA)
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Patent
Country of Publication:
United States
Language:
English

Citation Formats

McElhanon, James R, and Shepodd, Timothy J. Detection of Electrophilic and Nucleophilic Chemical Agents. United States: N. p., 2008. Web.
McElhanon, James R, & Shepodd, Timothy J. Detection of Electrophilic and Nucleophilic Chemical Agents. United States.
McElhanon, James R, and Shepodd, Timothy J. 2008. "Detection of Electrophilic and Nucleophilic Chemical Agents". United States. https://www.osti.gov/servlets/purl/953735.
@article{osti_953735,
title = {Detection of Electrophilic and Nucleophilic Chemical Agents},
author = {McElhanon, James R and Shepodd, Timothy J},
abstractNote = {A "real time" method for detecting electrophilic and nucleophilic species generally by employing tunable, precursor sensor materials that mimic the physiological interaction of these agents to form highly florescent berberine-type alkaloids that can be easily and rapidly detected. These novel precursor sensor materials can be tuned for reaction with both electrophilic (chemical species, toxins) and nucleophilic (proteins and other biological molecules) species.},
doi = {},
url = {https://www.osti.gov/biblio/953735}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Nov 11 00:00:00 EST 2008},
month = {Tue Nov 11 00:00:00 EST 2008}
}

Works referenced in this record:

The fluorescence properties of protoberberine and tetrahydroprotoberberine alkaloids
journal, January 1976