Detection of Electrophilic and Nucleophilic Chemical Agents
Abstract
A "real time" method for detecting electrophilic and nucleophilic species generally by employing tunable, precursor sensor materials that mimic the physiological interaction of these agents to form highly florescent berberine-type alkaloids that can be easily and rapidly detected. These novel precursor sensor materials can be tuned for reaction with both electrophilic (chemical species, toxins) and nucleophilic (proteins and other biological molecules) species.
- Inventors:
-
- Manteca, CA
- Livermore, CA
- Publication Date:
- Research Org.:
- Sandia National Lab. (SNL-CA), Livermore, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 953735
- Patent Number(s):
- 7,449,579
- Application Number:
- Assignee:
- Sandia Corporation (Livermore, CA)
- DOE Contract Number:
- AC04-94AL85000
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
Citation Formats
McElhanon, James R, and Shepodd, Timothy J. Detection of Electrophilic and Nucleophilic Chemical Agents. United States: N. p., 2008.
Web.
McElhanon, James R, & Shepodd, Timothy J. Detection of Electrophilic and Nucleophilic Chemical Agents. United States.
McElhanon, James R, and Shepodd, Timothy J. 2008.
"Detection of Electrophilic and Nucleophilic Chemical Agents". United States. https://www.osti.gov/servlets/purl/953735.
@article{osti_953735,
title = {Detection of Electrophilic and Nucleophilic Chemical Agents},
author = {McElhanon, James R and Shepodd, Timothy J},
abstractNote = {A "real time" method for detecting electrophilic and nucleophilic species generally by employing tunable, precursor sensor materials that mimic the physiological interaction of these agents to form highly florescent berberine-type alkaloids that can be easily and rapidly detected. These novel precursor sensor materials can be tuned for reaction with both electrophilic (chemical species, toxins) and nucleophilic (proteins and other biological molecules) species.},
doi = {},
url = {https://www.osti.gov/biblio/953735},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Nov 11 00:00:00 EST 2008},
month = {Tue Nov 11 00:00:00 EST 2008}
}
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Works referenced in this record:
The fluorescence properties of protoberberine and tetrahydroprotoberberine alkaloids
journal, January 1976
- Pavelka, S.; Smékal, E.
- Collection of Czechoslovak Chemical Communications, Vol. 41, Issue 10