Optical Coherence Tomography and Raman Spectroscopy of the retina
Imaging the structure and correlating it with the biochemical content of the retina holds promise for fundamental research and for clinical applications. Optical coherence tomography (OCT) is commonly used to image the 3D structure of the retina and while the added functionality of biochemical analysis afforded by Raman scattering could provide critical molecular signatures for clinicians and researchers, there are many technical challenges to combining these imaging modalities. We present an ex vivo OCT microscope combined with Raman spectroscopy capable of collecting morphological and molecular information about a sample simultaneously. The combined instrument will be used to investigate remaining technical challenges to combine these imaging modalities, such as the laser power levels needed to achieve a Raman signal above the noise level without damaging the sample.
- Research Organization:
- Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- W-7405-ENG-48
- OSTI ID:
- 948213
- Report Number(s):
- LLNL-PROC-410601; TRN: US200906%%295
- Resource Relation:
- Journal Volume: 7171; Conference: Presented at: Photonics West, San Jose, CA, United States, Jan 24 - Jan 29, 2009
- Country of Publication:
- United States
- Language:
- English
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