skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Automated High Throughput Drug Target Crystallography

Abstract

The molecular structures of drug target proteins and receptors form the basis for 'rational' or structure guided drug design. The majority of target structures are experimentally determined by protein X-ray crystallography, which as evolved into a highly automated, high throughput drug discovery and screening tool. Process automation has accelerated tasks from parallel protein expression, fully automated crystallization, and rapid data collection to highly efficient structure determination methods. A thoroughly designed automation technology platform supported by a powerful informatics infrastructure forms the basis for optimal workflow implementation and the data mining and analysis tools to generate new leads from experimental protein drug target structures.

Authors:
Publication Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
936949
Report Number(s):
UCRL-JRNL-209860
TRN: US200821%%150
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Journal Article
Journal Name:
American Pharmaceutical Review, N/A, no. 9/10, September 1, 2005, pp. 14
Additional Journal Information:
Journal Issue: 9/10
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; AUTOMATION; CRYSTALLIZATION; CRYSTALLOGRAPHY; DESIGN; IMPLEMENTATION; MINING; MOLECULAR STRUCTURE; PROTEINS; TARGETS

Citation Formats

Rupp, B. Automated High Throughput Drug Target Crystallography. United States: N. p., 2005. Web.
Rupp, B. Automated High Throughput Drug Target Crystallography. United States.
Rupp, B. 2005. "Automated High Throughput Drug Target Crystallography". United States. https://www.osti.gov/servlets/purl/936949.
@article{osti_936949,
title = {Automated High Throughput Drug Target Crystallography},
author = {Rupp, B},
abstractNote = {The molecular structures of drug target proteins and receptors form the basis for 'rational' or structure guided drug design. The majority of target structures are experimentally determined by protein X-ray crystallography, which as evolved into a highly automated, high throughput drug discovery and screening tool. Process automation has accelerated tasks from parallel protein expression, fully automated crystallization, and rapid data collection to highly efficient structure determination methods. A thoroughly designed automation technology platform supported by a powerful informatics infrastructure forms the basis for optimal workflow implementation and the data mining and analysis tools to generate new leads from experimental protein drug target structures.},
doi = {},
url = {https://www.osti.gov/biblio/936949}, journal = {American Pharmaceutical Review, N/A, no. 9/10, September 1, 2005, pp. 14},
number = 9/10,
volume = ,
place = {United States},
year = {Fri Feb 18 00:00:00 EST 2005},
month = {Fri Feb 18 00:00:00 EST 2005}
}