Comment on ``Experimental Free Energy Reconstruction From Single-Molecule Force Spectroscopy Using Jarzynski's Equality''
Abstract
Harris, Song and Kiang [1] (HSK) describe their results on reconstructing the free energy profiles for both the stretch of the titin polymer, and the unfolding of an individual I27 domain. The new finding reported in [1] is the measurement of the free energy barrier (or activation energy) to unfolding the I27 domain. Due to a misinterpretation of the mechanics involved, the free energy surface (and thus the energy barrier) to unfolding the I27 domain was not measured.
- Authors:
- Publication Date:
- Research Org.:
- Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 928521
- Report Number(s):
- LLNL-JRNL-400499
Journal ID: ISSN 0031-9007; PRLTAO; TRN: US0803279
- DOE Contract Number:
- W-7405-ENG-48
- Resource Type:
- Journal Article
- Journal Name:
- Physical Review Letters
- Additional Journal Information:
- Journal Volume: 100; Journal Issue: 1; Journal ID: ISSN 0031-9007
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY; ACTIVATION ENERGY; FREE ENERGY; SPECTROSCOPY
Citation Formats
Friddle, R W. Comment on ``Experimental Free Energy Reconstruction From Single-Molecule Force Spectroscopy Using Jarzynski's Equality''. United States: N. p., 2008.
Web. doi:10.1103/PhysRevLett.100.019801.
Friddle, R W. Comment on ``Experimental Free Energy Reconstruction From Single-Molecule Force Spectroscopy Using Jarzynski's Equality''. United States. https://doi.org/10.1103/PhysRevLett.100.019801
Friddle, R W. 2008.
"Comment on ``Experimental Free Energy Reconstruction From Single-Molecule Force Spectroscopy Using Jarzynski's Equality''". United States. https://doi.org/10.1103/PhysRevLett.100.019801. https://www.osti.gov/servlets/purl/928521.
@article{osti_928521,
title = {Comment on ``Experimental Free Energy Reconstruction From Single-Molecule Force Spectroscopy Using Jarzynski's Equality''},
author = {Friddle, R W},
abstractNote = {Harris, Song and Kiang [1] (HSK) describe their results on reconstructing the free energy profiles for both the stretch of the titin polymer, and the unfolding of an individual I27 domain. The new finding reported in [1] is the measurement of the free energy barrier (or activation energy) to unfolding the I27 domain. Due to a misinterpretation of the mechanics involved, the free energy surface (and thus the energy barrier) to unfolding the I27 domain was not measured.},
doi = {10.1103/PhysRevLett.100.019801},
url = {https://www.osti.gov/biblio/928521},
journal = {Physical Review Letters},
issn = {0031-9007},
number = 1,
volume = 100,
place = {United States},
year = {Mon Jan 14 00:00:00 EST 2008},
month = {Mon Jan 14 00:00:00 EST 2008}
}
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Works referenced in this record:
Free energy reconstruction from nonequilibrium single-molecule pulling experiments
journal, March 2001
- Hummer, G.; Szabo, A.
- Proceedings of the National Academy of Sciences, Vol. 98, Issue 7
Experimental Free Energy Surface Reconstruction from Single-Molecule Force Spectroscopy using Jarzynski’s Equality
journal, August 2007
- Harris, Nolan C.; Song, Yang; Kiang, Ching-Hwa
- Physical Review Letters, Vol. 99, Issue 6
Free Energy Surfaces from Single-Molecule Force Spectroscopy
journal, July 2005
- Hummer, Gerhard; Szabo, Attila
- Accounts of Chemical Research, Vol. 38, Issue 7