Disruption of Maternal DNA Repair Increases Sperm-DerivedChromosomal Aberrations

Journal Article · Wed Feb 07 00:00:00 EST 2007 · Proceedings of the National Academy ofSciences

OSTI ID:922724

Marchetti, Francesco; Essers, Jeroun; Kanaar, Roland; Wyrobek, Andrew J

The final weeks of male germ cell differentiation occur in aDNA repair-deficient environment and normal development depends on theability of the egg to repair DNA damage in the fertilizing sperm. Geneticdisruption of maternal DNA double-strand break repair pathways in micesignificantly increased the frequency of zygotes with chromosomalstructural aberrations after paternal exposure to ionizing radiation.These findings demonstrate that radiation-induced DNA sperm lesions arerepaired after fertilization by maternal factors and suggest that geneticvariation in maternal DNA repair can modulate the risk of early pregnancylosses and of children with chromosomal aberrations of paternalorigin.

• Research Organization: Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
• Sponsoring Organization: USDOE Director, Office of Science; National Institutes ofHealth
• DOE Contract Number: DE-AC02-05CH11231; NIHNIH ES 09117-03
• OSTI ID: 922724
• Report Number(s): LBNL-62441; R&D Project: L0555; BnR: 600305000; TRN: US200804%%893
• Journal Information: Proceedings of the National Academy ofSciences, Vol. 104, Issue 45; Related Information: Journal Publication Date: 11/06/2007
• Country of Publication: United States
• Language: English

Related Subjects

59
BIOLOGICAL PATHWAYS
CHILDREN
CHROMOSOMAL ABERRATIONS
DNA
DNA DAMAGES
DNA REPAIR
FERTILIZATION
GENETICS
GERM CELLS
IONIZING RADIATIONS
MALES
MICE
ORIGIN
PREGNANCY
REPAIR
SPERMATOZOA
ZYGOTES
ionizing radiation DNA repair zygote chromosomalaberrations