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Title: Tissue-like phantoms

Patent ·
OSTI ID:918907

The invention is based, in part, on the discovery that by combining certain components one can generate a tissue-like phantom that mimics any desired tissue, is simple and inexpensive to prepare, and is stable over many weeks or months. In addition, new multi-modal imaging objects (e.g., beads) can be inserted into the phantoms to mimic tissue pathologies, such as cancer, or merely to serve as calibration standards. These objects can be imaged using one, two, or more (e.g., four) different imaging modalities (e.g., x-ray computed tomography (CT), positron emission tomography (PET), single photon emission computed tomography (SPECT), and near-infrared (NIR) fluorescence) simultaneously.

Research Organization:
Beth Israel Deaconess Medical Center, Inc. (Boston, MA)
Sponsoring Organization:
USDOE
DOE Contract Number:
FG02-01ER63188
Assignee:
Beth Israel Deaconess Medical Center, Inc. (Boston, MA)
Patent Number(s):
7,288,759
Application Number:
11/222,949
OSTI ID:
918907
Country of Publication:
United States
Language:
English

References (15)

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Optical CT reconstruction of 3D dose distributions using the ferrous-benzoic-xylenol (FBX) gel dosimeter journal September 1998
In vivo near-infrared fluorescence imaging of osteoblastic activity journal December 2001
An Operational Near-Infrared Fluorescence Imaging System Prototype for Large Animal Surgery journal December 2003
Sub-Millimeter Technetium-99m Calibration Sources journal October 2002
A review of the optical properties of biological tissues journal January 1990
Tissue-like phantoms for near-infrared fluorescence imaging system assessment and the training of surgeons journal January 2006
Quantitative analysis of near-infrared tomography: sensitivity to the tissue-simulating precalibration phantom journal January 2003
A solid tissue phantom for photon migration studies journal October 1997
Determining the optical properties of turbid media by using the adding–doubling method journal January 1993
Glucose determination by a pulsed photoacoustic technique: an experimental study using a gelatin-based tissue phantom journal December 1993
An optical phantom with tissue-like properties in the visible for use in PDT and fluorescence spectroscopy journal July 1997

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