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Title: Apolipoprotein gene involved in lipid metabolism

Abstract

Methods and materials for studying the effects of a newly identified human gene, APOAV, and the corresponding mouse gene apoAV. The sequences of the genes are given, and transgenic animals which either contain the gene or have the endogenous gene knocked out are described. In addition, single nucleotide polymorphisms (SNPs) in the gene are described and characterized. It is demonstrated that certain SNPs are associated with diseases involving lipids and triglycerides and other metabolic diseases. These SNPs may be used alone or with SNPs from other genes to study individual risk factors. Methods for intervention in lipid diseases, including the screening of drugs to treat lipid-related or diabetic diseases are also disclosed.

Inventors:
 [1];  [2]
  1. Berkeley, CA
  2. Sebastopol, CA
Publication Date:
Research Org.:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
Sponsoring Org.:
Office of Biological and Environmental Research
OSTI Identifier:
913257
Patent Number(s):
7,238,475
Application Number:
10/229,834
Assignee:
The Regents of The University of California (Oakland, CA)
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Rubin, Edward, and Pennacchio, Len A. Apolipoprotein gene involved in lipid metabolism. United States: N. p., 2007. Web.
Rubin, Edward, & Pennacchio, Len A. Apolipoprotein gene involved in lipid metabolism. United States.
Rubin, Edward, and Pennacchio, Len A. 2007. "Apolipoprotein gene involved in lipid metabolism". United States. https://www.osti.gov/servlets/purl/913257.
@article{osti_913257,
title = {Apolipoprotein gene involved in lipid metabolism},
author = {Rubin, Edward and Pennacchio, Len A},
abstractNote = {Methods and materials for studying the effects of a newly identified human gene, APOAV, and the corresponding mouse gene apoAV. The sequences of the genes are given, and transgenic animals which either contain the gene or have the endogenous gene knocked out are described. In addition, single nucleotide polymorphisms (SNPs) in the gene are described and characterized. It is demonstrated that certain SNPs are associated with diseases involving lipids and triglycerides and other metabolic diseases. These SNPs may be used alone or with SNPs from other genes to study individual risk factors. Methods for intervention in lipid diseases, including the screening of drugs to treat lipid-related or diabetic diseases are also disclosed.},
doi = {},
url = {https://www.osti.gov/biblio/913257}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jul 03 00:00:00 EDT 2007},
month = {Tue Jul 03 00:00:00 EDT 2007}
}

Works referenced in this record:

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Increased risk for endogenous hypertriglyceridaemia is associated with an apolipoprotein C3 haplotype specified by theSstI polymorphism
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DNA polymorphisms of apolipoprotein A-I/C-III and insulin genes in familial hypertriglyceridemia and coronary heart disease
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ApoC-III gene polymorphisms and risk of coronary artery disease
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Polymorphic Markers in Apolipoprotein C-III Gene Flanking Regions and Hypertriglyceridemia
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The genetic effect of the apoprotein AV gene on the serum triglyceride level in Japanese
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Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels
journal, November 2002


Genetic variation in the apolipoprotein AI-CIII-AIV gene cluster and coronary heart disease
journal, October 1988


Variation in the apo AI/CIII/AIV gene complex: its association with hyperlipidemia
journal, December 1989


Haplotypes of the ApoA-I/C-III/A-IV Gene Cluster and Familial Combined Hyperlipidemia
journal, November 1998


Dna Polymorphism Adjacent to Human Apoprotein a-1 Gene: Relation to Hypertriglyceridaemia
journal, February 1983


Apolipoprotein A-V: A NOVEL APOLIPOPROTEIN ASSOCIATED WITH AN EARLY PHASE OF LIVER REGENERATION
journal, September 2001


The apoAI-CIII-AIV gene cluster
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A Genome Scan for Familial Combined Hyperlipidemia Reveals Evidence of Linkage with a Locus on Chromosome 11
journal, August 1999


An apolipoprotein CIII haplotype protective against hypertriglyceridemia is specified by promoter and 3' untranslated region polymorphisms.
journal, May 1993


Study of DNA polymorphisms of the apolipoprotein AI-CIII-AIV gene cluster in patients with peripheral arterial disease
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Regression of Atherosclerosis Induced by Liver-Directed Gene Transfer of Apolipoprotein A-I in Mice
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HTS in the new millennium
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Two newly identified SNPs in the APO AI-CIII intergenic region are strongly associated with familial combined hyperlipidaemia
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Variation at the apo AI/CIII/A1V gene complex is associated with elevated plasma levels of apo CIII
journal, April 1991