Allele-specific deposition of macroH2A1 in Imprinting Control Regions

Choo, J H; Kim, J D; Chung, J H; Stubbs, L; Kim, J

doi:10.1093/hmg/ddi485

Title: Allele-specific deposition of macroH2A1 in Imprinting Control Regions

Journal Article · Fri Jan 13 00:00:00 EST 2006 · Human Molecular Genetics, vol. 15, no. 5, March 1, 2006, pp. 717-724

DOI:https://doi.org/10.1093/hmg/ddi485· OSTI ID:898013

Choo, J H; Kim, J D; Chung, J H; Stubbs, L; Kim, J

In the current study, we analyzed the deposition patterns of macroH2A1 at a number of different genomic loci located in X chromosome and autosomes. MacroH2A1 is preferentially deposited at methylated CpG CpG-rich regions located close to promoters. The macroH2A1 deposition patterns at the methylated CpG islands of several imprinted domains, including the Imprinting Control Regions (ICRs) of Xist, Peg3, H19/Igf2 Igf2, Gtl2/Dlk1, and Gnas domains, show consistent allele-specificity towards inactive, methylated alleles. The macroH2A1 deposition levels at the ICRs and other Differentially Methylated Regions (DMRs) of these domains are also either higher or comparable to those observed at the inactive X chromosome of female mammals. Overall, our results indicate that besides DNA methylation macroH2A1 is another epigenetic component in the chromatin of ICRs displaying differential association with two parental alleles.

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Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: W-7405-ENG-48

OSTI ID:: 898013

Report Number(s):: UCRL-JRNL-218174; TRN: US200706%%192

Journal Information:: Human Molecular Genetics, vol. 15, no. 5, March 1, 2006, pp. 717-724, Journal Name: Human Molecular Genetics, vol. 15, no. 5, March 1, 2006, pp. 717-724

Country of Publication:: United States

Language:: English

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59 BASIC BIOLOGICAL SCIENCES
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