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Title: DNA Sliding Clamps: Just the Right Twist to Load onto DNA

Abstract

Two recent papers illuminate a long sought step in DNA sliding clamp loading. One paper reveals the structure of the PCNA clamp wrapped around DNA--still open from being loaded--while a second paper discovers that the clamp may assist this process by forming a right-handed helix upon opening.

Authors:
;
Publication Date:
Research Org.:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
885400
Report Number(s):
UCRL-JRNL-216541
TRN: US200616%%547
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Journal Article
Journal Name:
Current Biology
Additional Journal Information:
Journal Volume: 15; Journal Issue: 24
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; DNA; GENETIC ENGINEERING; BIOTECHNOLOGY

Citation Formats

Barsky, D, and Venclovas, C. DNA Sliding Clamps: Just the Right Twist to Load onto DNA. United States: N. p., 2005. Web. doi:10.1016/j.cub.2005.11.047.
Barsky, D, & Venclovas, C. DNA Sliding Clamps: Just the Right Twist to Load onto DNA. United States. https://doi.org/10.1016/j.cub.2005.11.047
Barsky, D, and Venclovas, C. 2005. "DNA Sliding Clamps: Just the Right Twist to Load onto DNA". United States. https://doi.org/10.1016/j.cub.2005.11.047. https://www.osti.gov/servlets/purl/885400.
@article{osti_885400,
title = {DNA Sliding Clamps: Just the Right Twist to Load onto DNA},
author = {Barsky, D and Venclovas, C},
abstractNote = {Two recent papers illuminate a long sought step in DNA sliding clamp loading. One paper reveals the structure of the PCNA clamp wrapped around DNA--still open from being loaded--while a second paper discovers that the clamp may assist this process by forming a right-handed helix upon opening.},
doi = {10.1016/j.cub.2005.11.047},
url = {https://www.osti.gov/biblio/885400}, journal = {Current Biology},
number = 24,
volume = 15,
place = {United States},
year = {Mon Oct 24 00:00:00 EDT 2005},
month = {Mon Oct 24 00:00:00 EDT 2005}
}

Works referenced in this record:

The PCNA–RFC Families of DNA Clamps and Clamp Loaders
book, January 2004


Proliferating cell nuclear antigen (PCNA): a dancer with many partners
journal, August 2003


CELLULAR DNA REPLICASES: Components and Dynamics at the Replication Fork
journal, June 2005


A Sliding-Clamp Toolbelt Binds High- and Low-Fidelity DNA Polymerases Simultaneously
journal, September 2005


Interaction of the   sliding clamp with MutS, ligase, and DNA polymerase I
journal, July 2001


Pre-steady State Analysis of the Assembly of Wild Type and Mutant Circular Clamps of Escherichia coli DNA Polymerase III onto DNA
journal, September 1998


Structural analysis of a eukaryotic sliding DNA clamp–clamp loader complex
journal, June 2004


Open clamp structure in the clamp-loading complex visualized by electron microscopic image analysis
journal, September 2005


Out-of-plane motions in open sliding clamps: Molecular dynamics simulations of eukaryotic and archaeal proliferating cell nuclear antigen
journal, September 2005


The internal workings of a DNA polymerase clamp-loading machine
journal, February 1999


ATP Utilization by Yeast Replication Factor C
journal, September 2001


Ordered ATP Hydrolysis in the γ Complex Clamp Loader AAA+ Machine
journal, April 2003


Crystal Structure of the Processivity Clamp Loader Gamma (γ) Complex of E. coli DNA Polymerase III
journal, August 2001