Final Technical Report
This project involved the development of a method for in vivo prompt gamma neutron activation analysis for the investigation of Boron-10 distribution in a rabbit knee. The overall objective of this work was a robust approach for rapid screening of new {sup 10}B-labelled compounds to determine their suitability for use in the treatment of rheumatoid arthritis via Boron Neutron Capture Synovectomy (BNCS). For BNCS it is essential to obtain a compound showing high uptake levels in the synovium and long residence time in the joints. Previously the in vivo uptake behavior of potential compounds was evaluated in the arthritic knee joints of rabbits via extensive dissection studies. These studies are very labor-intensive and involve sacrificing large numbers of animals. An in vivo {sup 10}B screening approach was developed to provide initial evaluation of potential compounds. Only those compounds showing positive uptake and retention characteristics will be evaluated further via dissection studies. No further studies will be performed with compounds showing rapid clearance and/or low synovial uptake. Two approaches to in vivo screening were investigated using both simulation methods and experimentation. Both make use of neutron beams generated at the MIT Research Reactor. The first, Transmission Computed Tomography (TCT) was developed and tested but was eventually rejected due to very limited spatial resolution using existing reactor beams. The second, in vivo prompt gamma neutron activation analysis (IVPGNAA) was much more promising. IVPGNAA was developed using computer simulation and physical measurement coupled with image reconstruction techniques. The method was tested in arthritic New Zealand rabbits previously injected intra-articularly with three boron labeled compounds and shown to be effective in providing information regarding uptake level and residence time of {sup 10}B in the joint.
- Research Organization:
- Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- fg07-02ID14343
- OSTI ID:
- 882513
- Report Number(s):
- DOE-14343-04; TRN: US0702707
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
73 NUCLEAR PHYSICS AND RADIATION PHYSICS
ANIMALS
BORON
BORON 10
CAPTURE
CLEARANCE
COMPUTERIZED SIMULATION
COMPUTERIZED TOMOGRAPHY
IN VIVO
NEUTRON ACTIVATION ANALYSIS
NEUTRON BEAMS
NEUTRON REACTIONS
RABBITS
RESEARCH REACTORS
RETENTION
RHEUMATIC DISEASES
SPATIAL RESOLUTION