Method And Apparatus For Examining A Tissue Using The Spectral Wing Emission Therefrom Induced By Visible To Infrared Photoexcitation.

Patent · Tue Dec 16 00:00:00 EST 2003

OSTI ID:879642

Alfano, Robert R ^[1]; Demos, Stavros G ^[2]; Zhang, Gang ^[3]

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1. 3777 Independence Ave., Bronx, NY 10463
2. 3550 Pacific Ave., Apt. 304, Livermore, CA 94550
3. 3 Rieder Rd., Edison, NJ 08817

Method and an apparatus for examining a tissue using the spectral wing emission therefrom induced by visible to infrared photoexcitation. In one aspect, the method is used to characterize the condition of a tissue sample and comprises the steps of (a) photoexciting the tissue sample with substantially monochromatic light having a wavelength of at least 600 nm; and (b) using the resultant far red and near infrared spectral wing emission (SW) emitted from the tissue sample to characterize the condition of the tissue sample. In one embodiment, the substantially monochromatic photoexciting light is a continuous beam of light, and the resultant steady-state far red and near infrared SW emission from the tissue sample is used to characterize the condition of the tissue sample. In another embodiment, the substantially monochromatic photoexciting light is a light pulse, and the resultant time-resolved far red and near infrared SW emission emitted from the tissue sample is used to characterize the condition of the tissue sample. In still another embodiment, the substantially monochromatic photoexciting light is a polarized light pulse, and the parallel and perpendicular components of the resultant polarized time-resolved SW emission emitted from the tissue sample are used to characterize the condition of the tissue sample.

• Research Organization: City Univ. of New York (CUNY), NY (United States)
• DOE Contract Number: FG02-98ER62560
• Assignee: Alfano, Robert R. (3777 Independence Ave., Bronx, NY 10463); Demos, Stavros G. (3550 Pacific Ave., Apt. 304, Livermore, CA 94550); Zhang, Gang (3 Rieder Rd., Edison, NJ 08817)
• Patent Number(s): US 6,665,556
• Application Number: 09/493939
• OSTI ID: 879642
• Country of Publication: United States
• Language: English