Process for the manufacture of 117Sn diethylenetriaminepentaacetic acids
Abstract
Novel methods are provided for the manufacture of .sup.117m Sn(Sn.sup.4+) DTPA. The method allows the use of DTPA, a toxic chelating agent, in an approximately 1:1 ratio to .sup.117m Sn(Sn.sup.4+) via either aqueous conditions, or using various organic solvents, such as methylene chloride. A pharmaceutical composition manufactured by the novel method is also provided, as well as methods for treatment of bone tumors and pain associated with bone cancer using the pharmaceutical composition of the invention.
- Inventors:
-
- Setauket, NY
- Upton, NY
- Middle Island, NY
- Publication Date:
- Research Org.:
- Brookhaven National Laboratory (BNL), Upton, NY (United States)
- OSTI Identifier:
- 875137
- Patent Number(s):
- US 6541514
- Assignee:
- Brookhaven Science Associates, LLC (Upton, NY)
- DOE Contract Number:
- AC02-98CH10886
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- process; manufacture; 117sn; diethylenetriaminepentaacetic; acids; novel; methods; provided; sup117m; snsnsup4; dtpa; method; allows; toxic; chelating; agent; approximately; 11; ratio; via; aqueous; conditions; organic; solvents; methylene; chloride; pharmaceutical; composition; manufactured; treatment; bone; tumors; pain; associated; cancer; organic solvent; chelating agent; acetic acid; /514/424/999/600/
Citation Formats
Srivastava, Suresh C, Li, Zizhong, and Meinken, George. Process for the manufacture of 117Sn diethylenetriaminepentaacetic acids. United States: N. p., 2003.
Web.
Srivastava, Suresh C, Li, Zizhong, & Meinken, George. Process for the manufacture of 117Sn diethylenetriaminepentaacetic acids. United States.
Srivastava, Suresh C, Li, Zizhong, and Meinken, George. 2003.
"Process for the manufacture of 117Sn diethylenetriaminepentaacetic acids". United States. https://www.osti.gov/servlets/purl/875137.
@article{osti_875137,
title = {Process for the manufacture of 117Sn diethylenetriaminepentaacetic acids},
author = {Srivastava, Suresh C and Li, Zizhong and Meinken, George},
abstractNote = {Novel methods are provided for the manufacture of .sup.117m Sn(Sn.sup.4+) DTPA. The method allows the use of DTPA, a toxic chelating agent, in an approximately 1:1 ratio to .sup.117m Sn(Sn.sup.4+) via either aqueous conditions, or using various organic solvents, such as methylene chloride. A pharmaceutical composition manufactured by the novel method is also provided, as well as methods for treatment of bone tumors and pain associated with bone cancer using the pharmaceutical composition of the invention.},
doi = {},
url = {https://www.osti.gov/biblio/875137},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Wed Jan 01 00:00:00 EST 2003},
month = {Wed Jan 01 00:00:00 EST 2003}
}
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Works referenced in this record:
Biodistribution of Sn-117m(4+)DTPA for palliative therapy of painful osseous metastases.
journal, January 1993
- Atkins, H. L.; Mausner, L. F.; Srivastava, S. C.
- Radiology, Vol. 186, Issue 1