Rosetta stone method for detecting protein function and protein-protein interactions from genome sequences

Eisenberg, David; Marcotte, Edward M; Pellegrini, Matteo; Thompson, Michael J; Yeates, Todd O

Title: Rosetta stone method for detecting protein function and protein-protein interactions from genome sequences

Patent · Tue Jan 01 00:00:00 EST 2002

OSTI ID:874814

Eisenberg, David ^[1]; Marcotte, Edward M ^[1]; Pellegrini, Matteo ^[2]; Thompson, Michael J ^[3]; Yeates, Todd O ^[4]

Los Angeles, CA
Sherman Oaks, CA
Santa Monica, CA
Agoura Hills, CA

A computational method system, and computer program are provided for inferring functional links from genome sequences. One method is based on the observation that some pairs of proteins A' and B' have homologs in another organism fused into a single protein chain AB. A trans-genome comparison of sequences can reveal these AB sequences, which are Rosetta Stone sequences because they decipher an interaction between A' and B. Another method compares the genomic sequence of two or more organisms to create a phylogenetic profile for each protein indicating its presence or absence across all the genomes. The profile provides information regarding functional links between different families of proteins. In yet another method a combination of the above two methods is used to predict functional links.

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Research Organization:: Univ. of California (United States)

DOE Contract Number:: FC03-87ER60615

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Number(s):: US 6466874

Application Number:: 09/493,497

OSTI ID:: 874814

Country of Publication:: United States

Language:: English

References (14)

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Title: Rosetta stone method for detecting protein function and protein-protein interactions from genome sequences

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References (14)

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