Customized oligonucleotide microchips that convert multiple genetic information to simple patterns, are portable and reusable

Mirzabekov, Andrei; Guschin, Dmitry Y; Chik, Valentine; Drobyshev, Aleksei; Fotin, Alexander; Yershov, Gennadiy; Lysov, Yuri

Title: Customized oligonucleotide microchips that convert multiple genetic information to simple patterns, are portable and reusable

Patent · Tue Jan 01 00:00:00 EST 2002

OSTI ID:874779

Mirzabekov, Andrei ^[1]; Guschin, Dmitry Y ^[2]; Chik, Valentine ^[3]; Drobyshev, Aleksei ^[4]; Fotin, Alexander ^[5]; Yershov, Gennadiy ^[6]; Lysov, Yuri ^[6]

Darien, IL
Rockville, MD
Woodridge, IL
Elektrosol, RU
Cambridge, MA
Hinsdale, IL

This invention relates to using customized oligonucleotide microchips as biosensors for the detection and identification of nucleic acids specific for different genes, organisms and/or individuals in the environment, in food and in biological samples. The microchips are designed to convert multiple bits of genetic information into simpler patterns of signals that are interpreted as a unit. Because of an improved method of hybridizing oligonucleotides from samples to microchips, microchips are reusable and transportable. For field study, portable laser or bar code scanners are suitable.

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Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

DOE Contract Number:: W-31109-ENG-38

Assignee:: University of Chicago (Chicago, IL)

Patent Number(s):: US 6458584

OSTI ID:: 874779

Country of Publication:: United States

Language:: English

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customized
oligonucleotide
microchips
convert
multiple
genetic
information
simple
patterns
portable
reusable
relates
biosensors
detection
identification
nucleic
acids
specific
genes
organisms
andor
individuals
environment
food
biological
samples
designed
bits
simpler
signals
interpreted
unit
improved
method
hybridizing
oligonucleotides
transportable
field
study
laser
bar
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scanners
nucleic acid
/435/999/

Title: Customized oligonucleotide microchips that convert multiple genetic information to simple patterns, are portable and reusable

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References (36)

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