Composition for detection of cell density signal molecule

Patent · Mon Jan 01 00:00:00 EST 2001

OSTI ID:873781

Schwarz, Richard I ^[1]

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1. Oakland, CA

Disclosed herein is a novel proteinaceous cell density signal molecule (CDS), which is secreted by fibroblastic cells in culture, preferably tendon cells, and which provides a means by which the cells self-regulate their proliferation and the expression of differentiated function. CDS, and the antibodies which recognize them, are important for the development of diagnostics and treatments for injuries and diseases involving connective tissues, particularly tendon. Also disclosed are methods of production and use.

• Research Organization: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
• DOE Contract Number: AC03-76SF00098
• Assignee: Regents of University of California (Oakland, CA)
• Patent Number(s): US 6245899
• OSTI ID: 873781
• Country of Publication: United States
• Language: English

Related Subjects

composition
detection
cell
density
signal
molecule
disclosed
novel
proteinaceous
cds
secreted
fibroblastic
cells
culture
preferably
tendon
provides
means
self-regulate
proliferation
expression
differentiated
function
antibodies
recognize
diagnostics
treatments
injuries
diseases
involving
connective
tissues
particularly
methods
production
cell density
signal molecule
density signal
proteinaceous cell
novel proteinaceous
tendon cells
tendon cell
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