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Title: Inhibition of cell-cell binding by lipid assemblies

Patent ·
OSTI ID:873748

This invention relates generally to the field of therapeutic compounds designed to interfere between the binding of ligands and their receptors on cell surface. More specifically, it provides products and methods for inhibiting cell migration and activation using lipid assemblies with surface recognition elements that are specific for the receptors involved in cell migration and activation.

Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
DOE Contract Number:
AC03-76SF00098
Assignee:
Regents of University of California (Oakland, CA)
Patent Number(s):
US 6235309
Application Number:
09/032377
OSTI ID:
873748
Country of Publication:
United States
Language:
English

References (121)

Oligosaccharide recognition by selectins: Synthesis and biological activity of multivalent sialyl lewis-X ligands journal November 1995
Peptides Which Bind to E-selectin and Block Neutrophil Adhesion journal September 1995
Molecular recognition and optical detection of biological pathogens at biomimetic membrane interfaces conference February 1997
Design and Synthesis of Glycomimetic Prototypes - A Model Sialyl Lewis x Ligand for E-Selectin journal January 1994
Novel sulfated ligands for the cell adhesion molecule E-selectin revealed by the neoglycolipid technology among O-linked oligosaccharides on an ovarian cystadenoma glycoprotein journal September 1992
Ligand Recognition by E-Selectin: Synthesis, Inhibitory Activity and Conformational Analysis of Bivalent Sialyl Lewis x Analogs journal January 1995
ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex journal November 1990
Intervention of carbohydrate recognition by proteins and nucleic acids. journal October 1996
Structure and energetics of protein-carbohydrate complexes journal October 1994
Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice journal July 1994
In vivo neutralization of P-selectin protects feline heart and endothelium in myocardial ischemia and reperfusion injury. journal June 1993
Synthesis of phospholipid-inhibitor conjugates by enzymic transphosphatidylation with phospholipase D journal November 1993
Selectins as potential targets of therapeutic intervention in inflammatory diseases journal June 1994
Endothelial-Leukocyte Adhesion Molecules journal April 1993
P-selectin glycoprotein ligand-1 mediates rolling of human neutrophils on P-selectin. journal February 1995
Cardioprotection by liposome-conjugated sialyl Lewisx-oligosaccharide in myocardial ischaemia and reperfusion injury journal December 1995
Granule membrane protein 140 (GMP140) binds to carcinomas and carcinoma-derived cell lines. journal March 1992
Adjunctive Selectin Blockade Successfully Reduces Infarct Size Beyond Thrombolysis in the Electrolytic Canine Coronary Artery Model journal August 1995
Direct Colorimetric Detection of Virus by a Polymerized Bilayer Assembly journal January 1993
Selectin-Carbohydrate Interactions and the Initiation of the Inflammatory Response journal June 1995
Liposome-like fucopeptides as sialyl lewis X mimetics journal November 1996
A central role for microvillous receptor presentation in leukocyte adhesion under flow journal September 1995
Inhibition of insulitis and prevention of diabetes in nonobese diabetic mice by blocking L-selectin and very late antigen 4 adhesion receptors. journal November 1993
Polysulfated Derivatives of β-Cyclodextrin andmyo-Inositol as Potent Inhibitors of the Interaction between L-Selectin and Peripheral Addressin: Implying a Requirement for Highly Clustered Sulfate Groups journal December 1996
Antigen-induced Acute and Late-phase Responses in Primates journal August 1992
Molecular assemblies of functionalized polydiacetylenes journal January 1995
The selectins and their ligands journal October 1994
Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog. journal May 1983
Polymerizable Phospholipid Analogues—New Stable Biomembrane and Cell Models journal November 1980
Shear-dependent inhibition of granulocyte adhesion to cultured endothelium by dextran sulfate journal April 1989
Adhesion Molecules in the Lung: An Overview journal December 1993
Preparation and characterization of liposomes as therapeutic delivery systems: a review journal July 1995
Synthesis of bioactive sialosides journal January 1993
Multiple Sialyl Lewisx N-Glycopeptides: Effective Ligands for E-Selectin journal February 1996
Adhesion molecules in autoimmune disease journal February 1996
Liposomes from polymerizable phospholipids journal November 1983
Tyrosine Sulfation of P-selectin Glycoprotein Ligand-1 Is Required for High Affinity Binding to P-selectin journal September 1995
Quantitation of L-selectin distribution on human leukocyte microvilli by immunogold labeling and electron microscopy. journal August 1996
Pitfalls in the synthesis and biological evaluation of sialyl-LewisX mimetics as potential selectin antagonists journal February 1997
Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm journal January 1994
CD62 and endothelial cell-leukocyte adhesion molecule 1 (ELAM-1) recognize the same carbohydrate ligand, sialyl-Lewis x. journal July 1991
Synthesis and structural analysis using 2-D NMR of sialyl Lewis X (SLex) and Lewis X (Lex) oligosaccharides: ligands related to E-selectin [ELAM-1] binding. journal June 1992
Supramolecular assemblies, a crystal structure, and a polymer of N-diacetylenic gluconamides journal September 1991
Role of endothelial-leukocyte adhesion molecule 1 (ELAM-1) in neutrophil-mediated lung injury in rats. journal October 1991
6'-Sulfated Sialyl Lewis x Is a Major Capping Group of GlyCAM-1 journal April 1994
Lifetime of the P-selectin-carbohydrate bond and its response to tensile force in hydrodynamic flow journal April 1995
Therapeutic Effects of Antibodies Against Adhesion Molecules in Murine Collagen Type II-Induced Arthritis journal January 1995
Molecular Architecture and Function of Polymeric Oriented Systems: Models for the Study of Organization, Surface Recognition, and Dynamics of Biomembranes journal January 1988
Glycolipids as Immunomodulators: Syntheses and Properties journal December 1991
Lymphocyte homing into lymph nodes: in vitro demonstration of the selective affinity of recirculating lymphocytes for high-endothelial venules. journal September 1976
Synthesis of sialyl Lewis X mimetics: Use of O-α-fucosyl-(1R, 2R)-2-aminocyclohexanol as core structure journal July 1996
Effects of membrane composition and lipid structure on the photopolymerization of lipid diacetylenes in bilayer membranes journal December 1982
Anionic phospholipids bind to L-selectin (but not E-selectin) at a site distinct from the carbohydrate-binding site journal February 1996
Syntheses and some applications of chemically defined multivalent glycoconjugates journal October 1996
Enzyme Catalysis in Synthetic Carbohydrate Chemistry journal January 1991
Physiological and Molecular Mechanisms of Lymphocyte Homing journal April 1992
Polymerized Liposomes and Vesicles book July 2019
Supramolecular assemblies of diacetylenic aldonamides journal September 1991
Synthesis of antigenic carbohydrate polymers recognized by lectins and antibodies journal January 1988
Subsets of sialylated, sulfated mucins of diverse origins are recognized by L-selectin. Lack of evidence for unique oligosaccharide sequences mediating binding journal January 1996
Enhanced Biochemical Affinities of Multivalent Neoglycoconjugates book January 1994
The Practice of Peptide Synthesis book January 1984
Reduction of rat myocardial ischemia and reperfusion injury by sialyl Lewis x oligosaccharide and anti-rat P-selectin antibodies journal January 1996
Polymerization of diacetylene carbonic acid monolayers at the gas-water interface journal May 1978
DNA aptamers block L-selectin function in vivo. Inhibition of human lymphocyte trafficking in SCID mice. journal December 1996
Lymphocyte interactions with endothelial cells journal January 1992
Structure--function studies on selectin carbohydrate ligands. Modifications to fucose, sialic acid and sulphate as a sialic acid replacement journal December 1993
Synthesis of a Divalent Sialyl Lewis x O-glycan, a Potent Inhibitor of Lymphocyte-Endothelium Adhesion. Evidence that Multivalency Enhances the Saccharide Binding to L-selectin journal December 1995
Enzyme-catalyzed synthesis of carbohydrates journal January 1989
Combined glycomimetic and multivalent strategies for the design of potent selectin antagonists journal June 1996
PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminus journal October 1995
The three members of the selectin receptor family recognize a common carbohydrate epitope, the sialyl Lewis(x) oligosaccharide journal May 1992
Oligosaccharides that mediate mammalian cell-cell adhesion journal October 1993
A ‘litmus test’ for molecular recognition using artificial membranes journal February 1996
Selectins and their ligands: current concepts and controversies journal November 1996
Inositol polyanions. Noncarbohydrate inhibitors of L- and P-selectin that block inflammation. journal May 1994
Higher-affinity oligosaccharide ligands for E-selectin. journal March 1993
Cytokine-induced meningitis is dramatically attenuated in mice deficient in endothelial selectins. journal June 1996
Tumor necrosis factor participates in the pathogenesis of acute immune complex alveolitis in the rat. journal December 1989
Sialyl Lewis x Liposomes as a Multivalent Ligand and Inhibitor of E-Selectin Mediated Cellular Adhesion journal January 1996
The chemical-enzymatic synthesis of a carbon glycoside of N-acetyl neuraminic acid journal August 1991
Selectin ligands. journal August 1994
Differential Expression of ICAM-1 and LFA-1 versus L-selectin and VCAM-1 in Autoimmune Insulitis of NOD Mice and Association with both Th1- and Th2-type Infiltrates journal October 1996
Heparin oligosaccharides bind L- and P-selectin and inhibit acute inflammation journal December 1993
Monoclonal antibody to L-selectin attenuates neutrophil accumulation and protects ischemic reperfused cat myocardium. journal August 1993
Polymerized liposomes containing C-glycosides of sialic acid: potent inhibitors of influenza virus in vitro infectivity journal February 1993
Selectins: interpreters of cell-specific carbohydrate information during inflammation journal November 1992
The Synthesis of Novel 6-Amido-6-Deoxy-L-Galactose Derivatives as Potent Sialyl Lewisx Mimetics journal November 1996
Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets journal October 1992
Leukocyte adhesion: Two selectins converge on sulphate journal March 1996
The role of Adhesion Molecules in the Pathogenesis of Rheumatoid Arthritis journal January 1993
Polydiacetylene Liposomes Functionalized with Sialic Acid Bind and Colorimetrically Detect Influenza Virus journal January 1995
The complement binding-like domains of the murine homing receptor facilitate lectin activity. journal October 1991
Attenuation of the Inflammatory Response in an Animal Colitis Model by Neutrophil Inhibitory Factor, a Novel β 2 -Integrin Antagonist journal January 1996
Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemie myocardium journal November 1985
Leukocyte trafficking mediated by selectin-carbohydrate interactions journal May 1995
Multivalent sialyl-LeX: potent inhibitors of E-selectin-mediated cell adhesion; reagent for staining activated endothelial cells journal January 1994
Direct colorimetric detection of a receptor-ligand interaction by a polymerized bilayer assembly journal July 1993
An Efficient Synthesis of N -Allylglycosylamides from Unprotected Carbohydrates journal January 1996
Sulphation requirement for GlyCAM-1, an endothelial ligand for L-selectin journal February 1993
A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding journal October 1995
Synthetic Bilayer Membranes with Anionic Head Groups journal June 1978
Up-Regulation of Endothelial Cell Adhesion Molecules Characterizes Disease Activity in Systemic Lupus Erythematosus journal March 1994
Pulmonary vascular injury induced by hemorrhagic shock is mediated by P-selectin in rats journal April 1996
Structural and functional characterization of monomeric soluble P-selectin and comparison with membrane P-selectin journal July 1993
Anti-adhesive therapeutics: A new class of anti-inflammatory agents journal July 1994
Glycomimetic selectin inhibitors: (α-D-mannopyranosyloxy)methylbiphenyls journal March 1996
Rapid neutrophil adhesion to activated endothelium mediated by GMP-140 journal February 1990
Selectins. journal February 1993
Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system. journal December 1987
Possible role for cell-surface carbohydrate-binding molecules in lymphocyte recirculation. journal March 1983
Rational Design and Synthesis of a 1,1-Linked Disaccharide That Is 5 Times as Active as Sialyl Lewis X in Binding to E-Selectin journal January 1996
CD62/P-selectin recognition of myeloid and tumor cell sulfatides journal October 1991
Sulfated disaccharide with greater inhibitory potency for L-selectin than sialyl Lewis x journal November 1995
Studies on Selectin Blockers. 2. Novel Selectin Blocker as Potential Therapeutics for Inflammatory Disorders journal January 1996
Calcium-dependent heparin-like ligands for L-selectin in nonlymphoid endothelial cells journal July 1993
Highly stereoselective c-allylation of glycopyranosides with allylsilanes catalyzed by silyl triflate or iodosilane journal January 1984
The HNK-1 reactive sulfoglucuronyl glycolipids are ligands for L-selectin and P-selectin but not E-selectin. journal February 1993
GMP-140 binds to a glycoprotein receptor on human neutrophils: evidence for a lectin-like interaction. journal February 1991
Specific Interaction of Influenza Virus with Organized Assemblies of Polydiacetylenes journal January 1992
Enzyme-catalyzed oligosaccharide synthesis journal May 1992