Radiopharmaceutical stannic Sn-117m chelate compositions and methods of use
- Setauket, NY
- Middle Island, NY
Radiopharmaceutical compositions including .sup.117m Sn labeled stannic (Sn.sup.4+) chelates are provided. The chelates are preferably polyhydroxycarboxylate, such as oxalates, tartrates, citrates, malonates, gluconates, glucoheptonates and the like. Methods of making .sup.117m Sn-labeled (Sn.sup.4+) polyhydroxycarboxylic chelates are also provided. The foregoing pharmaceutical compositions can be used in methods of preparing bone for scintigraphical analysis, for radiopharmaceutical skeletal imaging, treatment of pain resulting from metastatic bone involvement, treatment of primary bone cancer, treatment of cancer resulting from metastatic spread to bone from other primary cancers, treatment of pain resulting from rheumatoid arthritis, treatment of bone/joint disorders and to monitor radioactively the skeletal system.
- Research Organization:
- Brookhaven National Laboratory (BNL), Upton, NY (United States)
- DOE Contract Number:
- AC02-98CH10886
- Assignee:
- Brookhaven Science Associates (Upton, NY)
- Patent Number(s):
- US 6231832
- OSTI ID:
- 873731
- Country of Publication:
- United States
- Language:
- English
The development and in-vivo behavior of tin containing radiopharmaceuticals—II. Autoradiographic and scintigraphic studies in normal animals and in animal models of bone disease
|
journal | January 1985 |
Biodistribution of Sn-117m(4+)DTPA for palliative therapy of painful osseous metastases.
|
journal | January 1993 |
Tin-117m: Production, chemistry and evaluation as a bone-scanning agent
|
journal | June 1973 |
The development and in-vivo behavior of tin containing radiopharmaceuticals—I. Chemistry, preparation, and biodistribution in small animals
|
journal | January 1985 |
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Related Subjects
stannic
sn-117m
chelate
compositions
methods
including
117m
labeled
chelates
provided
preferably
polyhydroxycarboxylate
oxalates
tartrates
citrates
malonates
gluconates
glucoheptonates
sn-labeled
polyhydroxycarboxylic
foregoing
pharmaceutical
preparing
bone
scintigraphical
analysis
skeletal
imaging
treatment
pain
resulting
metastatic
involvement
primary
cancer
spread
cancers
rheumatoid
arthritis
joint
disorders
monitor
radioactively
compositions including
pharmaceutical compositions
radiopharmaceutical composition
pharmaceutical composition
rheumatoid arthritis
sn-117m chelate
bone cancer
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