Method for photo-altering a biological system to improve biological effect

Patent · Tue Aug 01 00:00:00 EDT 2000

OSTI ID:873120

Hill, Richard A ^[1]; Doiron, Daniel R ^[2]; Crean, David H ^[3]

---

1. Irvine, CA
2. Santa Ynez, CA
3. Santa Barbara, CA

Photodynamic therapy is a new adjunctive therapy for filtration surgery that does not use chemotherapy agents or radiation, but uses pharmacologically-active sensitizing compounds to produce a titratable, localized, transient, post operative avascular conjunctiva. A photosensitizing agent in a biological system is selectively activated by delivering the photosensitive agent to the biological system and laser activating only a spatially selected portion of the delivered photosensitive agent. The activated portion of the photosensitive agent reacts with the biological system to obtain a predetermined biological effect. As a result, an improved spatial disposition and effectuation of the biological effect by the photosensitive agent in the biological system is achieved.

• DOE Contract Number: 44514322443
• Assignee: Regents of University of California (Oakland, CA)
• Patent Number(s): US 6095147
• Application Number: 08/347,956
• OSTI ID: 873120
• Country of Publication: United States
• Language: English

Related Subjects

method
photo-altering
biological
improve
effect
photodynamic
therapy
adjunctive
filtration
surgery
chemotherapy
agents
radiation
pharmacologically-active
sensitizing
compounds
produce
titratable
localized
transient
post
operative
avascular
conjunctiva
photosensitizing
agent
selectively
activated
delivering
photosensitive
laser
activating
spatially
selected
portion
delivered
reacts
obtain
predetermined
result
improved
spatial
disposition
effectuation
achieved
selected portion
photodynamic therapy
selectively activated
improved spatial
selectively activate
activated portion
/128/604/