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Title: Opto-acoustic thrombolysis

Patent ·
OSTI ID:872842
 [1];  [2];  [3];  [4];  [3];  [5];  [3]
  1. Berkeley, CA
  2. Danville, CA
  3. Livermore, CA
  4. Orinda, CA
  5. Moss Beach, CA
+ Show Author Affiliations

This invention is a catheter-based device for generating an ultrasound excitation in biological tissue. Pulsed laser light is guided through an optical fiber to provide the energy for producing the acoustic vibrations. The optical energy is deposited in a water-based absorbing fluid, e.g. saline, thrombolytic agent, blood or thrombus, and generates an acoustic impulse in the fluid through thermoelastic and/or thermodynamic mechanisms. By pulsing the laser at a repetition rate (which may vary from 10 Hz to 100 kHz) an ultrasonic radiation field can be established locally in the medium. This method of producing ultrasonic vibrations can be used in vivo for the treatment of stroke-related conditions in humans, particularly for dissolving thrombus or treating vasospasm. The catheter can also incorporate thrombolytic drug treatments as an adjunct therapy and it can be operated in conjunction with ultrasonic detection equipment for imaging and feedback control and with optical sensors for characterization of thrombus type and consistency.

Research Organization:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
DOE Contract Number:
W-7405-ENG-48
Assignee:
Regents of University of California (Oakland, CA)
Patent Number(s):
US 6022309
OSTI ID:
872842
Country of Publication:
United States
Language:
English

References (20)

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Recanalization of arteries by laser radiation journal January 1984
Numerical studies of bubble dynamics in laser thrombolysis conference May 1996
Initial clinical experience with a new pulsed dye laser device in angioplasty of limb ischemia and shunt fistula obstructions journal January 1992
Effect of pulse duration on bubble formation and laser-induced pressure waves during holmium laser ablation journal January 1996
Multifiber Optically-Shielded Catheter For Laser Angiosurgery conference April 1987
Investigation of cavitation bubble dynamics using particle image velocimetry: implications for photoacoustic drug delivery conference May 1996
Selective photothermolysis: precise microsurgery by selective absorption of pulsed radiation journal April 1983
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Effects of carbon dioxide, Nd-YAG, and argon laser radiation on coronary atheromatous plaques journal December 1982
Bubble formation during pulsed laser ablation: mechanism and implications
  • van Leeuwen, Ton G. J. M.; Jansen, E. Duco; Motamedi, Massoud
  • OE/LASE'93: Optics, Electro-Optics, & Laser Applications in Science& Engineering, SPIE Proceedings https://doi.org/10.1117/12.147658
conference July 1993
Preferential ablation of calcified arterial plaque with laser-induced plasmas journal October 1987
Human coronary laser recanalization: Human coronary laser recanalization journal July 1984
Multispot laser photocoagulation system using a fiber bundle scanner journal January 1982
Noncontact tissue ablation by Holmium: YSGG laser pulses in blood journal January 1991
A new concept for a realtime feedback system in angioplasty with a flashlamp pumped dye laser journal January 1991
Argon laser disintegration of thrombus and atherosclerotic plaque journal January 1984

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Related Subjects

opto-acoustic
thrombolysis
catheter-based
device
generating
ultrasound
excitation
biological
tissue
pulsed
laser
light
guided
optical
fiber
provide
energy
producing
acoustic
vibrations
deposited
water-based
absorbing
fluid
saline
thrombolytic
agent
blood
thrombus
generates
impulse
thermoelastic
thermodynamic
mechanisms
pulsing
repetition
rate
vary
10
hz
100
khz
ultrasonic
radiation
field
established
locally
medium
method
vivo
treatment
stroke-related
conditions
humans
particularly
dissolving
treating
vasospasm
catheter
incorporate
drug
treatments
adjunct
therapy
operated
conjunction
detection
equipment
imaging
feedback
control
sensors
characterization
type
consistency
optical sensors
repetition rate
optical fiber
laser light
pulsed laser
feedback control
optical energy
radiation field
optical sensor
biological tissue
stroke-related conditions
ultrasonic vibrations
acoustic vibrations
ultrasonic detection
detection equipment
acoustic vibration
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