skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Characterization of highly scattering media by measurement of diffusely backscattered polarized light

Patent ·
OSTI ID:872798
 [1];  [2];  [2]
  1. Brooklyn, NY
  2. Los Alamos, NM
+ Show Author Affiliations

An apparatus and method for recording spatially dependent intensity patterns of polarized light that is diffusely backscattered from highly scattering media are described. These intensity patterns can be used to differentiate different turbid media, such as polystyrene-sphere and biological-cell suspensions. Polarized light from a He-Ne laser (.lambda.=543 nm) is focused onto the surface of the scattering medium, and a surface area of approximately 4.times.4 cm centered on the light input point is imaged through polarization analysis optics onto a CCD camera. A variety of intensity patterns may be observed by varying the polarization state of the incident laser light and changing the analyzer configuration to detect different polarization components of the backscattered light. Experimental results for polystyrene-sphere and Intralipid suspensions demonstrate that the radial and azimuthal variations of the observed pattern depend on the concentration, size, and anisotropy factor, g, of the particles constituting the scattering medium. Measurements performed on biological cell suspensions show that intensity patterns can be used to differentiate between suspensions of cancerous and non-cancerous cells. Introduction of the Mueller-matrix for diffusely backscattered light, permits the selection of a subset of measurements which comprehensively describes the optical properties of backscattering media.

Research Organization:
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
DOE Contract Number:
W-7405-ENG-36
Assignee:
Regents of University of California (Los Alamos, NM)
Patent Number(s):
US 6011626
OSTI ID:
872798
Country of Publication:
United States
Language:
English

References (12)

Application of polarization effects in light scattering: a new biophysical tool. journal February 1976
Polarized light scattering from biological systems: A technique for cell differentiation journal June 1981
Video reflectometry to specify optical properties of tissue in vivo conference July 2017
Diffuse backscattering Mueller matricesof highly scattering media journal January 1997
Time resolved depolarization of multiple backscattered light from random media journal December 1989
Stokes vectors, Mueller matrices, and polarized scattered light journal May 1985
Spatially resolved absolute diffuse reflectance measurements for noninvasive determination of the optical scattering and absorption coefficients of biological tissue journal January 1996
Influence of particle size and concentration on the diffuse backscattering of polarized light from tissue phantoms and biological cell suspensions journal January 1997
Polarized Light Examination and Photography of the Skin journal July 1991
Photon pathlength distribution from polarized backscattering in random media journal August 1996
Polarized light transmission through skin using video reflectometry: toward optical tomography of superficial tissue layers conference May 1996
A diffusion theory model of spatially resolved, steady-state diffuse reflectance for the noninvasive determination of tissue optical properties in vivo journal July 1992

Similar Records

Related Subjects

characterization
highly
scattering
media
measurement
diffusely
backscattered
polarized
light
apparatus
method
recording
spatially
dependent
intensity
patterns
described
differentiate
turbid
polystyrene-sphere
biological-cell
suspensions
he-ne
laser
lambda
543
nm
focused
surface
medium
approximately
times
cm
centered
input
imaged
polarization
analysis
optics
ccd
camera
variety
observed
varying
incident
changing
analyzer
configuration
detect
components
experimental
results
intralipid
demonstrate
radial
azimuthal
variations
pattern
depend
concentration
size
anisotropy
factor
particles
constituting
measurements
performed
biological
cell
cancerous
non-cancerous
cells
introduction
mueller-matrix
permits
selection
subset
comprehensively
describes
optical
properties
backscattering
turbid media
highly scattering
ccd camera
incident laser
polarized light
scattered light
laser light
optical properties
scattering medium
scattering media
intensity patterns
experimental results
diffusely backscattered
intensity pattern
biological cell
/356/