Apparatus and method to control atmospheric water vapor composition and concentration during dynamic cooling of biological tissues in conjunction with laser irradiations
- Laguna Niguel, CA
- Houston, TX
- Irvine, CA
- Austin, TX
Cryogen spray cooling of skin surface with millisecond cryogen spurts is an effective method for establishing a controlled temperature distribution in tissue and protecting the epidermis from nonspecific thermal injury during laser mediated dermatological procedures. Control of humidity level, spraying distance and cryogen boiling point is material to the resulting surface temperature. Decreasing the ambient humidity level results in less ice formation on the skin surface without altering the surface temperature during the cryogen spurt. For a particular delivery nozzle, increasing the spraying distance to 85 millimeters lowers the surface temperature. The methodology comprises establishing a controlled humidity level in the theater of operation of the irradiation site of the biological tissues before and/or during the cryogenic spray cooling of the biological tissue. At cold temperatures calibration was achieved by mounting a thermistor on a thermoelectric cooler. The thermal electric cooler was cooled from from 20.degree. C. to about -20.degree. C. while measuring its infrared emission.
- Research Organization:
- Univ. of California (United States)
- DOE Contract Number:
- FG03-91ER61227
- Assignee:
- Regents of University of California (Oakland, CA)
- Patent Number(s):
- US 5997530
- OSTI ID:
- 872724
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
method
control
atmospheric
water
vapor
composition
concentration
dynamic
cooling
biological
tissues
conjunction
laser
irradiations
cryogen
spray
surface
millisecond
spurts
effective
establishing
controlled
temperature
distribution
tissue
protecting
epidermis
nonspecific
thermal
injury
mediated
dermatological
procedures
humidity
level
spraying
distance
boiling
material
resulting
decreasing
ambient
results
ice
formation
altering
spurt
particular
delivery
nozzle
increasing
85
millimeters
lowers
methodology
comprises
theater
operation
irradiation
site
cryogenic
cold
temperatures
calibration
achieved
mounting
thermistor
thermoelectric
cooler
electric
cooled
20
degree
-20
measuring
infrared
emission
spray cooling
laser irradiation
controlled temperature
infrared emission
water vapor
thermal electric
surface temperature
temperature distribution
biological tissue
cold temperature
effective method
laser media
comprises establishing
ice formation
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