Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids

Miller, Paul S; Ts'o, Paul O.P.

Title: Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids

Patent · Tue Jun 15 00:00:00 EDT 1999

OSTI ID:872330

Miller, Paul S ^[1]; Ts'o, Paul O.P. ^[2]

Baltimore, MD
Lutherville, MD

A composition for inactivating a target nucleic acid which comprises an oligonucleoside alkyl or arylphosphonate analogue which is complementary to the sequence of the target nucleic acid and includes a functional group which reacts with the target nucleic acid to render the target nucleic acid inactive or nonfunctional.

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Research Organization:: Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: FG02-88ER60636

Assignee:: Johns Hopkins University (Baltimore, MD)

Patent Number(s):: US 5912339

Application Number:: 08/342005

OSTI ID:: 872330

Country of Publication:: United States

Language:: English

References (12)

Effects of pendant groups at phosphorus on binding properties of d-ApA analogues Letsinger, R. L.; Bach, S. A.; Eadie, J. S. Nucleic Acids Research, Vol. 14, Issue 8 https://doi.org/10.1093/nar/14.8.3487	journal	January 1986
Sequence-specific cleavage of single-stranded DNA: oligodeoxynucleotide-EDTA X Fe(II). Dreyer, G. B.; Dervan, P. B. Proceedings of the National Academy of Sciences, Vol. 82, Issue 4 https://doi.org/10.1073/pnas.82.4.968	journal	February 1985
Antiviral effect of oligo(nucleoside methylphosphonates) complementary to the herpes simplex virus type 1 immediate early mRNAs 4 and 5 Kulka, Michael; Wachsman, Matthew; Miura, Shunsuke Antiviral Research, Vol. 20, Issue 2 https://doi.org/10.1016/0166-3542(93)90002-Z	journal	February 1993
Oligonucleotide Analogues as Potential Chemotherapeutic Agents Zon, Gerald Pharmaceutical Research, Vol. 05, Issue 9, p. 539-549 https://doi.org/10.1023/A:1015985728434	journal	January 1988
Chemical synthesis of natural and modified oligodeoxynucleotides Thuong, N.; Asseline, U. Biochimie, Vol. 67, Issue 7-8 https://doi.org/10.1016/S0300-9084(85)80155-3	journal	July 1985
Nonenzymatic sequence-specific cleavage of single-stranded DNA. Chu, B. C.; Orgel, L. E. Proceedings of the National Academy of Sciences, Vol. 82, Issue 4 https://doi.org/10.1073/pnas.82.4.963	journal	February 1985
Molecular Biology: Antisense Has Growing Pains Gura, T. Science, Vol. 270, Issue 5236 https://doi.org/10.1126/science.270.5236.575	journal	October 1995
CpG motifs in bacterial DNA trigger direct B-cell activation Krieg, Arthur M.; Yi, Ae-Kyung; Matson, Sara Nature, Vol. 374, Issue 6522 https://doi.org/10.1038/374546a0	journal	April 1995
Oligodeoxynucleotides covalently linked to intercalating agents: a new class of gene regulatory substances Helene, C.; Montenaygarestier, T.; Saison, T. Biochimie, Vol. 67, Issue 7-8 https://doi.org/10.1016/S0300-9084(85)80167-X	journal	July 1985
Interaction of psoralen-derivatized oligodeoxyribonucleoside methylphosphonates with single-stranded DNA Lee, Bok L.; Murakami, Akira; Blake, Kathleen R. Biochemistry, Vol. 27, Issue 9 https://doi.org/10.1021/bi00409a011	journal	May 1988
Synthesis of porphyrin(Fe)-intercalators which cause DNA scission Hashimoto, Yuichi; Lee, Ching-Shing; Shudo, Koichi Tetrahedron Letters, Vol. 24, Issue 14 https://doi.org/10.1016/S0040-4039(00)81699-8	journal	January 1983
Hybridization triggered cross-linking of deoxyoligonucleotides Webb, Thomas R.; Matteucci, Mark D. Nucleic Acids Research, Vol. 14, Issue 19 https://doi.org/10.1093/nar/14.19.7661	journal	January 1986

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Related Subjects

oligonucleoside
alkyl
arylphosphonate
derivatives
capable
crosslinking
cleaving
nucleic
acids
composition
inactivating
target
acid
comprises
analogue
complementary
sequence
functional
reacts
render
inactive
nonfunctional
nucleic acid
nucleic acids
target nucleic
oligonucleoside alkyl
target nuclei
/999/435/

Title: Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids

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References (12)

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