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Title: Boronated porhyrins and methods for their use

Patent ·
OSTI ID:872173
 [1];  [2];  [3]
  1. Hampton Bays, NY
  2. Tijeras, NM
  3. Southhold, NY
+ Show Author Affiliations

The present invention covers boronated porphyrins containing multiple carborane cages which selectively accumulate in neoplastic tissue within the irradiation volume and thus can be used in cancer therapies such as boron neutron capture therapy and photodynamic therapy.

Research Organization:
Associated Universities, Inc., Upton, NY (United States)
DOE Contract Number:
AC02-76CH00016
Assignee:
Brookhaven Science Associates (Upton, NY)
Patent Number(s):
US 5877165
Application Number:
08/874548
OSTI ID:
872173
Country of Publication:
United States
Language:
English

References (7)

Synthesis and Spectroscopic Characterization of Octaacetic Acid Tetraphenylporphyrins journal December 1994
Synthesis, Tissue Uptake, and Toxicity of a Nickel Tetracarboranylphenylporphyrin book January 1996
Accumulation of Porphyrins in Cells: Influence of Hydrophobicity Aggregation and Protein Binding journal October 1988
Preparation of carboranyl porphyrins for boron neutron capture therapy journal January 1990
Synthesis of Pyrrole-3,4-diacetic Acid and Its Derivatives journal January 1989
Microanalytical techniques for boron analysis using the 1 0 B( n ,α) 7 Li reaction: Microanalysis for boron by the 1 0 B( n ,α) 7 Li reaction journal January 1986
Biodistribution and toxicity of 2,4-divinyl-nido-o-carboranyldeuteroporphyrin IX in mice journal February 1992

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boronated
porhyrins
methods
covers
porphyrins
containing
multiple
carborane
cages
selectively
accumulate
neoplastic
tissue
irradiation
volume
cancer
therapies
boron
neutron
capture
therapy
photodynamic
neutron capture
boron neutron
capture therapy
photodynamic therapy
boronated porphyrins
containing multiple
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