Method for protection against genotoxic mutagenesis

Grdina, David J

Title: Method for protection against genotoxic mutagenesis

Patent · Tue Feb 09 00:00:00 EST 1999

OSTI ID:872141

Grdina, David J ^[1]

Naperville, IL

A method and pharmaceutical for protecting against mutational damage in mammalian cells, irrespective of the nature of the mutagenic event or source of radiational or chemical insult or the like.

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Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

DOE Contract Number:: W-31109-ENG-38

Assignee:: Arch Development Corporation (Chicago, IL)

Patent Number(s):: US 5869338

Application Number:: 08/481885

OSTI ID:: 872141

Country of Publication:: United States

Language:: English

References (59)

Protection against radiation-induced mutagenesis at the hprt locus by spermine and N, N ″-(dithiodi-2, 1-ethanediyl)bis-1,3-propanediamine (WR-33278) Shigematsu, N.; Schwartz, J. L.; Grdina, D. J. Mutagenesis, Vol. 9, Issue 4 https://doi.org/10.1093/mutage/9.4.355	journal	January 1994
Differential radioprotection of cultured human diploid fibroblasts and fibrosarcoma cells by WR1065 Zhang, Xiafang; Lai, Peter; Taylor, Ybonne International Journal of Radiation OncologyBiologyPhysics, Vol. 21 https://doi.org/10.1016/0360-3016(91)90458-G	journal	January 1991
Thiol and disulfide metabolites of the radiation protector and potential chemopreventive agent WR-2721 are linked to both its anti-cytotoxic and anti-mutagenic mechanisms of action Grdina, David J.; Shigematsu, Naoyuki; Dale, Phylis Carcinogenesis, Vol. 16, Issue 4 https://doi.org/10.1093/carcin/16.4.767	journal	January 1995
Protection against Radiation-Induced Mutagenesis in V79 Cells by 2-[(Aminopropyl)amino] Ethanethiol under Conditions of Acute Hypoxia Grdina, David J.; Nagy, Biserka; Hill, Colin K. Radiation Research, Vol. 117, Issue 2 https://doi.org/10.2307/3577326	journal	February 1989
The effect of 2-[(aminopropyl)amino] ethanethiol on fission-neutron-induced DNA damage and repair Grdina, Dj; Sigdestad, Cp; Dale, Pj British Journal of Cancer, Vol. 59, Issue 1 https://doi.org/10.1038/bjc.1989.5	journal	January 1989
A Comparison of Radioprotection from Three Neutron Sources and 60 Co by WR-2721 and WR-151327 Sigdestad, Curtis P.; Grdina, David J.; Connor, A. M. Radiation Research, Vol. 106, Issue 2 https://doi.org/10.2307/3576796	journal	May 1986
Differential Effects of Radical Scavengers on X-Ray-Induced Mutation and Cytotoxicity in Human Cells Corn, Benjamin W.; Liber, Howard L.; Little, John B. Radiation Research, Vol. 109, Issue 1 https://doi.org/10.2307/3576871	journal	January 1987
Protection against AZT-induced mutagenesis at the HGPRT locus in a human cell line by WR-151326 Grdina, D. J.; Dale, P.; Weichselbaum, R. International Journal of Radiation OncologyBiologyPhysics, Vol. 22, Issue 4 https://doi.org/10.1016/0360-3016(92)90530-U	journal	January 1992
Cell Cycle Redistribution of Cultured Cells After Treatment With Chemical Radiation Protectors Sigdestad, C. P.; Guilford, W.; Perrin, J. Cell Proliferation, Vol. 21, Issue 3 https://doi.org/10.1111/j.1365-2184.1988.tb00857.x	journal	May 1988
The inhibitory effect of cysteine on the mutagenic activities of several carcinogens Rosin, Miriam P.; Stich, H. F. Mutation Research/Environmental Mutagenesis and Related Subjects, Vol. 54, Issue 1 https://doi.org/10.1016/0165-1161(78)90137-1	journal	August 1978
The effects of cycloheximide and WR-1065 on radiation-induced repair processes: a mechanism for chemoprevention Murley, Jeffrey S.; Grdina, David J. Carcinogenesis, Vol. 16, Issue 11 https://doi.org/10.1093/carcin/16.11.2699	journal	January 1995
The radioprotector WR-2721 reduces neutron-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in mouse splenocytes when administered prior to or following irradiation Grdina, David J.; Kataoka, Yasushi; Basic, Ivan Carcinogenesis, Vol. 13, Issue 5 https://doi.org/10.1093/carcin/13.5.811	journal	January 1992
Chemical protection and cell-cycle effects on radiation-induced mutagenesis Grdina, D. J.; Sigdestad, C. P. Cell Proliferation, Vol. 25, Issue 1 https://doi.org/10.1111/j.1365-2184.1992.tb01434.x	journal	January 1992
Radiation-induced DNA Single-strand Breaks in the Intestinal Mucosal Cells of Mice Treated with the Radioprotectors WR-2721 or 16-16 Dimethyl Prostaglandin E ₂ Hanson, Wayne R.; Grdina, David J. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, Vol. 52, Issue 1 https://doi.org/10.1080/09553008714551491	journal	January 1987
Binding of aminoalkylphosphorothioate radioprotective drugs to rodent tissue proteins Livesey, John C.; Grunbaum, Zdenka; Krohn, Kenneth A. Biochemical Pharmacology, Vol. 39, Issue 11 https://doi.org/10.1016/0006-2952(90)90129-9	journal	June 1990
Radioprotection by wr-151327 against the late normal tissue damage in mouse hind legs from gamma ray radiation Matsushita, Satoru; Ando, Koichi; Koike, Sachiko International Journal of Radiation OncologyBiologyPhysics, Vol. 30, Issue 4 https://doi.org/10.1016/0360-3016(94)90362-X	journal	November 1994
The effect of 2-[(aminopropyl)amino] ethanethiol (WR-1065) on radiation induced DNA double strand damage and repair in V79 cells Sigdestad, Cp; Treacy, Sh; Knapp, La British Journal of Cancer, Vol. 55, Issue 5 https://doi.org/10.1038/bjc.1987.97	journal	May 1987
Conformational changes in chromatin structure induced by the radioprotective aminothiol, WR 1065 Vaughan, Atm; Grdina, Dj; Meechan, Pj British Journal of Cancer, Vol. 60, Issue 6 https://doi.org/10.1038/bjc.1989.386	journal	December 1989
2-[(Aminopropyl)amino] Ethanethiol-Mediated Reductions in 60 Co g-Ray and Fission-Spectrum Neutron-Induced Chromosome Damage in V79 Cells Schwartz, Jeffrey L.; Giovanazzi, Susan M.; Karrison, Theodore Radiation Research, Vol. 113, Issue 1 https://doi.org/10.2307/3577187	journal	January 1988
The effect of topoisomerase inhibitors on the expression of differentiation markers and cell cycle progression in human K-562 leukemia cells Constantinou, Andreas; Grdina, David; Kiguchi, Kaoru Experimental Cell Research, Vol. 203, Issue 1 https://doi.org/10.1016/0014-4827(92)90044-9	journal	November 1992
The isoquinoline sulfonamide H7 attenuates radiation-mediated protein kinase C activation and delays the onset of x-ray-induced G2 arrest Hallahan, Dennis E.; Virudachalam, Subbulakshmi; Grdina, David International Journal of Radiation OncologyBiologyPhysics, Vol. 24, Issue 4 https://doi.org/10.1016/0360-3016(92)90715-T	journal	January 1992
Effects of growth media on cell cycle progression in CHO cells exposed to the radioprotector WR-1065 Murley, J. S.; Grdina, D. J.; Meechan, P. J. Cell Proliferation, Vol. 25, Issue 6 https://doi.org/10.1111/j.1365-2184.1992.tb01466.x	journal	November 1992
In Vivo Protection by the Aminothiol WR-2721 against Neutron-induced Carcinogenesis Carnes, B. A.; Grdina, D. J. International Journal of Radiation Biology, Vol. 61, Issue 5 https://doi.org/10.1080/09553009214551381	journal	January 1992
Pathological Effects of the Radiation Protector WR-151327 in Mice van Beek, M. E. A. B.; Doak, R. L.; Sigdestad, C. P. Radiation Research, Vol. 124, Issue 1 https://doi.org/10.2307/3577698	journal	October 1990
DNA, mutations and aging Kirkwood, T. B. L. Mutation Research/DNAging, Vol. 219, Issue 1 https://doi.org/10.1016/0921-8734(89)90035-0	journal	January 1989
Induction of hprt Mutations in Mice after Exposure to Fission-Spectrum Neutrons or 60 Co Gamma Rays Kataoka, Yasushi; Perrin, Jane; Grdina, David J. Radiation Research, Vol. 136, Issue 2 https://doi.org/10.2307/3578623	journal	November 1993
SHORT COMMUNICATION: 2-[(Aminopropyl)amino]ethanethiol (WR1065) is anti-neoplastic and anti-mutagenic when given during ⁶⁰ Co γ-ray irradiation Hill, Colin K.; Nagy, Biserka; Peraino, Carl Carcinogenesis, Vol. 7, Issue 4 https://doi.org/10.1093/carcin/7.4.665	journal	January 1986
Effects of radioprotectors on DNA damage and repair, proteins, and cell-cycle progression Grdina, David J.; Guilford, William H.; Sigdestad, Curtis P. Pharmacology & Therapeutics, Vol. 39, Issue 1-3 https://doi.org/10.1016/0163-7258(88)90051-4	journal	January 1988
Radiation Protectors: the Unexpected Benefits Grdina, David J.; Sigdestad, Curtis P. Drug Metabolism Reviews, Vol. 20, Issue 1 https://doi.org/10.3109/03602538908994143	journal	January 1989
Natural antioxidants as inhibitors of oxygen species induced mutagenicity Minnunni, M.; Wolleb, U.; Mueller, O. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 269, Issue 2 https://doi.org/10.1016/0027-5107(92)90200-L	journal	October 1992
Inhibition of topoisomerase II activity in repair-proficient CHO K1 cells by 2-[(aminopropyl)amino]ethanethiol (WR-1065) Grdina, D. J.; Constantinou, A.; Shigematsu, N. https://doi.org/10.2172/10184593	report	September 1992
The radioprotector WR1065 reduces radiation-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in V79 cells Grdina, David J.; Nagy, Biserka; Hill, Colin K. Carcinogenesis, Vol. 6, Issue 6 https://doi.org/10.1093/carcin/6.6.929	journal	January 1985
Mitochondrial DNA alterations as ageing-associated molecular events Wei, Yau-Huei Mutation Research/DNAging, Vol. 275, Issue 3-6 https://doi.org/10.1016/0921-8734(92)90019-L	journal	September 1992
Variation in radiation sensitivity during the cell cycle of two human squamous cell carcinomas Quiet, Coral A.; Weichselbaum, Ralph R.; Grdina, David J. International Journal of Radiation OncologyBiologyPhysics, Vol. 20, Issue 4 https://doi.org/10.1016/0360-3016(91)90016-W	journal	April 1991
The effect of 2-[(aminopropyl)amino] ethanethiol (WR1065) on radiation-induced DNA damage and repair and cell progression in V79 cells Grdina, D. J.; Nagy, B. British Journal of Cancer, Vol. 54, Issue 6 https://doi.org/10.1038/bjc.1986.264	journal	December 1986
Oxidative and other DNA damages as the basis of aging: a review Holmes, George E.; Bernstein, Carol; Bernstein, Harris Mutation Research/DNAging, Vol. 275, Issue 3-6 https://doi.org/10.1016/0921-8734(92)90034-M	journal	September 1992
Endogenous glutathione levels modulate the frequency of both spontaneous and long wavelength ultraviolet induced mutations in human cells Applegate, L. A.; Lautier, D.; Frenk, E. Carcinogenesis, Vol. 13, Issue 9 https://doi.org/10.1093/carcin/13.9.1557	journal	January 1992
Human pharmacokinetics of WR-2721 Shaw, Leslie M.; Turrisi, Andrew T.; Glover, Donna J. International Journal of Radiation OncologyBiologyPhysics, Vol. 12, Issue 8 https://doi.org/10.1016/0360-3016(86)90203-8	journal	August 1986
Accumulation of CHO Cells in G 2 Phase Following Exposure to WR-1065 Murley, Jeffrey S.; Grdina, David J.; Meechan, Paul J. Radiation Research, Vol. 126, Issue 2 https://doi.org/10.2307/3577822	journal	May 1991
Enhancement of Topoisomerase I-Mediated Unwinding of Supercoiled DNA by the Radioprotector WR-33278 Holwitt, Eric A.; Koda, Erik; Swenberg, C. E. Radiation Research, Vol. 124, Issue 1 https://doi.org/10.2307/3577703	journal	October 1990
Protection by WR-2721 and WR-151327 against late effects of gamma rays and neutrons Grdina, D. J.; Garnes, B. A.; Nagy, B. Advances in Space Research, Vol. 12, Issue 2-3 https://doi.org/10.1016/0273-1177(92)90115-E	journal	January 1992
The Increase in Radioresistance of Chinese Hamster Cells Cultured as Spheroids Is Correlated to Changes in Nuclear Morphology Gordon, David J.; Milner, Anne E.; Beaney, Ronald P. Radiation Research, Vol. 121, Issue 2 https://doi.org/10.2307/3577501	journal	February 1990
Preface: Aging of the 25th chromosome Joenje, Hans Mutation Research/DNAging, Vol. 275, Issue 3-6 https://doi.org/10.1016/0921-8734(92)90015-H	journal	September 1992
Chemical Protection against the Long-Term Effects of a Single Whole-Body Exposure of Mice to Ionizing Radiation: I. Life Shortening Maisin, J. R.; Mattelin, G.; Lambiet-Collier, M. Radiation Research, Vol. 71, Issue 1 https://doi.org/10.2307/3574717	journal	July 1977
Models for thiol protection of DNA in cells Held, Kathryn D. Pharmacology & Therapeutics, Vol. 39, Issue 1-3 https://doi.org/10.1016/0163-7258(88)90050-2	journal	January 1988
Protection by WR-2721 of human bone marrow function following irradiation Constine, Louis S.; Zagars, Gunar; Rubin, Philip International Journal of Radiation OncologyBiologyPhysics, Vol. 12, Issue 8 https://doi.org/10.1016/0360-3016(86)90204-X	journal	August 1986
The effect of chemical radiation protectors on cell cycle progression after gamma or neutron irradiation Sigdestad, C. P.; Bergquist, B. L.; Grdina, D. J. Cell Proliferation, Vol. 24, Issue 3 https://doi.org/10.1111/j.1365-2184.1991.tb01156.x	journal	May 1991
Protection by WR-151327 against Late-Effect Damage from Fission-Spectrum Neutrons Grdina, D. J.; Wright, B. J.; Carnes, B. A. Radiation Research, Vol. 128, Issue 1 https://doi.org/10.2307/3578014	journal	October 1991
Association of WR-1065 with CHO AA8 Cells, Nuclei, and Nucleoids Meechan, Paul J.; Vaughan, Andrew T. M.; Giometti, Carol S. Radiation Research, Vol. 125, Issue 2 https://doi.org/10.2307/3577882	journal	February 1991
Reversion of radiosensitivity in azacytidine-treated xrs5 cells does not result in full radioprotection by WR-1065 Meechan, Paul J.; Haraf, Daniel J.; Diamond, Alan M. International Journal of Radiation OncologyBiologyPhysics, Vol. 23, Issue 5 https://doi.org/10.1016/0360-3016(92)90905-W	journal	January 1992
Phase I Controlled trials of WR-2721 and cyclophosphamide Glick, John H.; Glover, Donna; Weiler, Clare International Journal of Radiation OncologyBiologyPhysics, Vol. 10, Issue 9 https://doi.org/10.1016/0360-3016(84)90548-0	journal	September 1984
Antimutagenic Effects of Radioprotector WR-2721 Against Fission-spectrum Neutrons and ⁶⁰ Co γ-rays in Mice Kataoka, Y.; Basic, I.; Perrin, J. International Journal of Radiation Biology, Vol. 61, Issue 3 https://doi.org/10.1080/09553009214551081	journal	January 1992
Inhibition of Topoisomerase IIα Activity in CHO K1 Cells by 2-[(Aminopropyl)Amino]Ethanethiol (WR-1065) Grdina, David J.; Constantinou, Andreas; Shigematsu, Naoyuki Radiation Research, Vol. 138, Issue 1 https://doi.org/10.2307/3578845	journal	April 1994
Cellular radiosensitivity in V79 cells is linked to alterations in chromatin structure Gordon, David J.; Milner, Anne E.; Beaney, Ronald P. International Journal of Radiation OncologyBiologyPhysics, Vol. 19, Issue 5 https://doi.org/10.1016/0360-3016(90)90228-C	journal	November 1990
Radioprotectors in treatment therapy to reduce risk in secondary tumor induction Grdina, David J.; Nagy, Biserka; Sigdestad, Curtis P. Pharmacology & Therapeutics, Vol. 39, Issue 1-3 https://doi.org/10.1016/0163-7258(88)90035-6	journal	January 1988
Protection by WR1065 and WR151326 against Fission-Neutron-Induced Mutations at the HGPRT Locus in V79 Cells Grdina, David J.; Sigdestad, Curtis P.; Carnes, Bruce A. Radiation Research, Vol. 117, Issue 3 https://doi.org/10.2307/3577355	journal	March 1989
Mitochondrial DNA mutation and the ageing process: bioenergy and pharmacological intervention Linnane, Anthony W.; Zhang, Chunfang; Baumer, Alessandra Mutation Research/DNAging, Vol. 275, Issue 3-6 https://doi.org/10.1016/0921-8734(92)90023-I	journal	September 1992
Antimutagenic properties of WR 2721 and of a radioprotective mixture, ATP-AET-serotonin, with regard to X ray induced reciprocal translocations in mouse spermatogonia Benova, D. International Journal of Radiation OncologyBiologyPhysics, Vol. 13, Issue 1 https://doi.org/10.1016/0360-3016(87)90268-9	journal	January 1987
Protective effects of 2-[(aminopropyl)amino] ethanethiol against bleomycin and nitrogen mustard-induced mutagenicity in V79 cells Nagy, B.; Grdina, D. J. International Journal of Radiation OncologyBiologyPhysics, Vol. 12, Issue 8 https://doi.org/10.1016/0360-3016(86)90197-5	journal	August 1986

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mutagenesis
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Title: Method for protection against genotoxic mutagenesis

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