Surface-enhanced raman medical probes and system for disease diagnosis and drug testing

Patent · Fri Jan 01 00:00:00 EST 1999

OSTI ID:872119

Vo-Dinh, Tuan ^[1]

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1. Knoxville, TN

A probe for a surface-enhanced Raman scattering spectrometer includes a member of optically transmissive material for receiving the excitation radiation from a laser and for carrying the radiation emitted from a specimen to a detector. An end of the member for placing against the specimen has a coating that produces surface enhancement of the specimen during Raman scattering spectroscopic analysis. Specifically the coating is formed by a first layer of microparticles on the member and a metal layer over the first layer. The first layer may form a microstructure surface over which a metal layer is applied. Alternatively the coating may be a material containing microparticles of a metal. An optional layer of a material may be applied to the metal layer to concentrate onto the probe compounds of analytical interest onto the probe.

• Research Organization: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
• DOE Contract Number: AC05-96OR22464
• Assignee: Lockheed Martin Energy Research Corporation (Oak Ridge, TN)
• Patent Number(s): US 5864397
• OSTI ID: 872119
• Country of Publication: United States
• Language: English

Related Subjects

surface-enhanced
raman
medical
probes
disease
diagnosis
drug
testing
probe
scattering
spectrometer
optically
transmissive
material
receiving
excitation
radiation
laser
carrying
emitted
specimen
detector
placing
coating
produces
surface
enhancement
spectroscopic
analysis
specifically
formed
layer
microparticles
metal
form
microstructure
applied
alternatively
containing
optional
concentrate
compounds
analytical
excitation radiation
surface-enhanced raman
spectroscopic analysis
raman scattering
metal layer
material containing
radiation emitted
enhanced raman
scattering spectrometer
transmissive material
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