Diagnostic method employing MSH2 protein
Patent
·
OSTI ID:871976
- Bergmansgatan, FI
- Baltimore, MD
The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error.sup.+ (RER.sup.+) tumor cells.
- Research Organization:
- ELEANOR ROOSEVELT INSTITUTE
- DOE Contract Number:
- FG02-91ER61139
- Assignee:
- Johns Hopkins University (Baltimore, MD)
- Patent Number(s):
- US 5837443
- OSTI ID:
- 871976
- Country of Publication:
- United States
- Language:
- English
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diagnostic
method
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identified
virtue
homology
muts
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cdna
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germ
line
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hnpcc
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replication
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method
employing
msh2
protein
human
responsible
hereditary
non-polyposis
colorectal
cancer
identified
virtue
homology
muts
genes
involved
dna
mismatch
repair
sequence
cdna
clones
provided
demonstrate
existence
germ
line
mutations
hnpcc
kindreds
replication
error
rer
tumor
cells
non-polyposis colorectal
colorectal cancer
cdna clones
cdna clone
diagnostic method
hereditary non-polyposis
tumor cells
replication error
mismatch repair
method employing
human msh2
germ line
msh2 protein
dna mismatch
line mutations
employing msh2
method employ
/435/530/