Method of detoxifying animal suffering from overdose

Mehlhorn, Rolf J

Title: Method of detoxifying animal suffering from overdose

Patent · Wed Jan 01 00:00:00 EST 1997

OSTI ID:870908

Mehlhorn, Rolf J ^[1]

Richmond, CA

A method for accumulating drugs or other chemicals within synthetic, lipid-like vesicles by means of a pH gradient imposed on the vesicles just prior to use is described. The method is suited for accumulating molecules with basic or acid moieties which are permeable to the vesicles membranes in their uncharged form and for molecules that contain charge moieties that are hydrophobic ions and can therefore cross the vesicle membranes in their charged form. The method is advantageous over prior art methods for encapsulating biologically active materials within vesicles in that it achieves very high degrees of loading with simple procedures that are economical and require little technical expertise, furthermore kits which can be stored for prolonged periods prior to use without impairment of the capacity to achieve drug accumulation are described. A related application of the method consists of using this technology to detoxify animals that have been exposed to poisons with basic, weak acid or hydrophobic charge groups within their molecular structure.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

DOE Contract Number:: AC03-76SF00098

Assignee:: Regents of University of California (Alameda, CA)

Patent Number(s):: US 5622713

OSTI ID:: 870908

Country of Publication:: United States

Language:: English

References (17)

[43] Light-induced pH gradients measured with spin-labeled amine and carboxylic acid probes: Application to Halobacterium halobium cell envelope vesicles Mehlhorn, R. J.; Probst, I. Biomembranes Part I: Visual Pigments and Purple Membranes II https://doi.org/10.1016/0076-6879(82)88046-4	book	January 1982
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The effect of lipid composition of small unilamellar liposomes containing melphalan and vincristine on drug clearance after injection into mice Kirby, Christopher; Gregoriadis, Gregory Biochemical Pharmacology, Vol. 32, Issue 4 https://doi.org/10.1016/0006-2952(83)90483-5	journal	February 1983
Uptake of antineoplastic agents into large unilamellar vesicles in response to a membrane potential Mayer, Lawrence D.; Bally, Marcel B.; Hope, Michael J. Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 816, Issue 2 https://doi.org/10.1016/0005-2736(85)90497-3	journal	June 1985
Increase in lipid microviscosity of unilamellar vesicles upon the creation of transmembrane potential Corda, D.; Pasternak, C.; Shinitzky, M. The Journal of Membrane Biology, Vol. 65, Issue 3 https://doi.org/10.1007/BF01869967	journal	October 1982
Light-induced proton gradients and internal volumes in chromatophores of Rhodopseudomonas sphaeroides Melandri, B. Andrea; Mehlhorn, Rolf J.; Packer, Lester Archives of Biochemistry and Biophysics, Vol. 235, Issue 1 https://doi.org/10.1016/0003-9861(84)90258-3	journal	November 1984
Active proton uptake by chromaffin granules: observation by amine distribution and phosphorus-31 nuclear magnetic resonance techniques Casey, Robert P.; Njus, David; Radda, George K. Biochemistry, Vol. 16, Issue 5 https://doi.org/10.1021/bi00624a025	journal	March 1977
Membrane Transport of Sugars and Amino Acids Reinhold, L.; Kaplan, A. Annual Review of Plant Physiology, Vol. 35, Issue 1 https://doi.org/10.1146/annurev.pp.35.060184.000401	journal	June 1984
Pyranine as a sensitive pH probe for liposome interiors and surfaces. pH gradients across phospholipid vesicles Kano, Koji; Fendler, Janos H. Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 509, Issue 2 https://doi.org/10.1016/0005-2736(78)90048-2	journal	May 1978
Preparation and characteristics of lipid vesicles Miyamoto, Vernon K.; Stoeckenius, Walther The Journal of Membrane Biology, Vol. 4, Issue 1 https://doi.org/10.1007/BF02431974	journal	December 1971
Measurement of Transmembrane Potentials in Phospholipid Vesicles Kornberg, R. D.; McNamee, M. G.; McConnell, H. M. Proceedings of the National Academy of Sciences, Vol. 69, Issue 6 https://doi.org/10.1073/pnas.69.6.1508	journal	June 1972
リポソーム系における光酸化還元反応と膜電位 Shinbo, Toshio; Sugiura, Masaaki; Kamo, Naoki NIPPON KAGAKU KAISHI, Issue 6 https://doi.org/10.1246/nikkashi.1983.917	journal	January 1983
Electrogenic H+/OH- movement across phospholipid vesicles measured by spin-labeled hydrophobic ions Cafiso, D. S.; Hubbell, W. L. Biophysical Journal, Vol. 44, Issue 1 https://doi.org/10.1016/S0006-3495(83)84276-3	journal	October 1983
The response of fluorescent amines to pH gradients across liposome membranes Deamer, David W.; Prince, Roger C.; Crofts, Antony R. Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 274, Issue 2 https://doi.org/10.1016/0005-2736(72)90180-0	journal	August 1972
Uptake of safranine and other lipophilic cations into model membrane systems in response to a membrane potential Bally, M. B.; Hope, M. J.; Van Echteld, C. J. A. Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 812, Issue 1 https://doi.org/10.1016/0005-2736(85)90522-X	journal	January 1985
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Mechanism of lactose translocation in proteoliposomes reconstituted with lac carrier protein purified from Escherichia coli. I. Effect of pH and imposed membrane potential on efflux, exchange, and counterflow Garcia, Maria Luisa; Viitanen, Paul; Foster, David L. Biochemistry, Vol. 22, Issue 10 https://doi.org/10.1021/bi00279a033	journal	May 1983

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Title: Method of detoxifying animal suffering from overdose

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References (17)

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