New multifunctional ligands for potential use in the design therapeutic or diagnostic radiopharmaceutical imaging agents

Katti, Kattesh V; Volkert, Wynn A; Ketring, Alan R; Singh, Prahlad R

Title: New multifunctional ligands for potential use in the design therapeutic or diagnostic radiopharmaceutical imaging agents

Patent · Wed Jan 01 00:00:00 EST 1997

OSTI ID:870821

Katti, Kattesh V ^[1]; Volkert, Wynn A ^[1]; Ketring, Alan R ^[1]; Singh, Prahlad R ^[1]

Columbia, MO

A class of diagnostic and therapeutic compounds derived from phosphinimines that include ligands containing either a single phosphinimine functionality or both a phosphinimine group and a phosphine or arsine group, or an aminato group, or a second phosphinimine moiety. These phosphinimine ligands are complexed to early transition metal radionuclides (e.g. .sup.99m Tc or .sup.186 Re/.sup.188 Re) or late transition metals (e.g., .sup.105 Rh or .sup.109 Pd). The complexes with these metals .sup.186 Re/.sup.188 Re, .sup.99m Tc and .sup.109 Pd exhibit a high in vitro and high in vivo stability. The complexes are formed in high yields and can be neutral or charged. These ligands can also be used to form stable compounds with paramagnetic transition metals (e.g. Fe and Mn) for potential use as MRI contrast agents. Applications for the use of ligands and making the ligands are also disclosed.

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Research Organization:: Univ. of Missouri, Columbia, MO (United States)

DOE Contract Number:: FG02-89ER60875

Assignee:: Curators of University of Missouri (Columbia, MO)

Patent Number(s):: US 5601800

OSTI ID:: 870821

Country of Publication:: United States

Language:: English

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Title: New multifunctional ligands for potential use in the design therapeutic or diagnostic radiopharmaceutical imaging agents

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