Silicon-based sleeve devices for chemical reactions

Patent · Mon Jan 01 00:00:00 EST 1996

OSTI ID:870757

Northrup, M Allen ^[1]; Carrano, Anthony V ^[2]; Balch, Joseph W ^[2]

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1. Berkeley, CA
2. Livermore, CA

A silicon-based sleeve type chemical reaction chamber that combines heaters, such as doped polysilicon for heating, and bulk silicon for convection cooling. The reaction chamber combines a critical ratio of silicon and silicon nitride to the volume of material to be heated (e.g., a liquid) in order to provide uniform heating, yet low power requirements. The reaction chamber will also allow the introduction of a secondary tube (e.g., plastic) into the reaction sleeve that contains the reaction mixture thereby alleviating any potential materials incompatibility issues. The reaction chamber may be utilized in any chemical reaction system for synthesis or processing of organic, inorganic, or biochemical reactions, such as the polymerase chain reaction (PCR) and/or other DNA reactions, such as the ligase chain reaction, which are examples of a synthetic, thermal-cycling-based reaction. The reaction chamber may also be used in synthesis instruments, particularly those for DNA amplification and synthesis.

• Research Organization: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
• DOE Contract Number: W-7405-ENG-48
• Assignee: Regents of University of California (Oakland, CA)
• Patent Number(s): US 5589136
• OSTI ID: 870757
• Country of Publication: United States
• Language: English

Related Subjects

silicon-based
sleeve
devices
chemical
reactions
type
reaction
chamber
combines
heaters
doped
polysilicon
heating
bulk
silicon
convection
cooling
critical
ratio
nitride
volume
material
heated
liquid
provide
uniform
power
requirements
allow
introduction
secondary
tube
plastic
contains
mixture
alleviating
potential
materials
incompatibility
issues
utilized
synthesis
processing
organic
inorganic
biochemical
polymerase
chain
pcr
dna
ligase
examples
synthetic
thermal-cycling-based
instruments
particularly
amplification
power requirements
uniform heating
chain reaction
silicon nitride
reaction chamber
reaction mixture
chemical reaction
polymerase chain
chemical reactions
bulk silicon
provide uniform
biochemical reactions
silicon-based sleeve
convection cooling
uniform heat
type chemical
power requirement
dna amplification
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