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Title: Dimeric fluorescent energy transfer dyes comprising asymmetric cyanine azole-indolenine chromophores

Patent ·
OSTI ID:870642
 [1];  [2]
  1. Orinda, CA
  2. Albany, CA
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Novel fluorescent DNA-staining dyes are provided combining asymmetric cyanine azole-indolenine dyes, which provide for strong DNA affinity, large Stokes shifts and emission in the red region of the spectrum. The dyes find particular application in gel electrophoresis and for labels which may be bound to a variety of compositions in a variety of contexts.

Research Organization:
Univ. of California (United States)
DOE Contract Number:
FG03-91ER61125
Assignee:
Regents of University of California (Oakland, CA)
Patent Number(s):
US 5565554
OSTI ID:
870642
Country of Publication:
United States
Language:
English

References (4)

Chemistry of Heterocyclic Compounds book January 1964
Cyanine dye labeling reagents for sulfhydryl groups journal January 1989
Heterodimeric DNA-binding dyes designed for energy transfer: stability and applications of the DNA complexes journal January 1993
Stable fluorescent complexes of double-stranded DNA with bis-intercalating asymmetric cyanine dyes: properties and applications journal January 1992

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dimeric
fluorescent
energy
transfer
dyes
comprising
asymmetric
cyanine
azole-indolenine
chromophores
novel
dna-staining
provided
combining
provide
strong
dna
affinity
stokes
shifts
emission
region
spectrum
particular
application
electrophoresis
labels
bound
variety
compositions
contexts
novel fluorescent
stokes shifts
particular application
energy transfer
transfer dyes
cyanine azole-indolenine
asymmetric cyanine
provided combining
strong dna
comprising asymmetric
combining asymmetric
fluorescent energy
stokes shift
azole-indolenine chromophores
azole-indolenine dyes
dyes comprising
dimeric fluorescent
dna affinity
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