Polypeptide having an amino acid replaced with N-benzylglycine

Mitchell, Alexander R; Young, Janis D

Title: Polypeptide having an amino acid replaced with N-benzylglycine

Patent · Mon Jan 01 00:00:00 EST 1996

OSTI ID:870479

Mitchell, Alexander R ^[1]; Young, Janis D ^[2]

Livermore, CA
Los Angeles, CA

The present invention relates to one or more polypeptides having useful biological activity in a mammal, which comprise: a polypeptide related to bradykinin of four to ten amino acid residues wherein one or more specific amino acids in the polypeptide chain are replaced with achiral N-benzylglycine. These polypeptide analogues have useful potent agonist or antagonist pharmacological properties depending upon the structure. A preferred polypeptide is (N-benzylglycine.sup.7)-bradykinin.

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Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Assignee:: Regents of University of California (Alameda, CA)

Patent Number(s):: US 5527882

OSTI ID:: 870479

Country of Publication:: United States

Language:: English

References (8)

Competitive antagonists of bradykinin Vavrek, Raymond J.; Stewart, John M. Peptides, Vol. 6, Issue 2 https://doi.org/10.1016/0196-9781(85)90033-6	journal	March 1985
Chapter 22. Luteinizing Hormone Releasing Hormone Analogs in Control of Fertility and Gonadal Hormone Dependent Disease Nestor, John J.; Vickery, Brian H. Annual Reports in Medicinal Chemistry https://doi.org/10.1016/S0065-7743(08)60850-7	book	January 1988
Über die Reduktion von aromatischen Alkoholen, Aldehyden und Ketonen. (Katalytische Hydrierungen ungesättigter Stoffe. X.) Skita, A. Berichte der deutschen chemischen Gesellschaft, Vol. 48, Issue 2 https://doi.org/10.1002/cber.19150480263	journal	July 1915
Hydrogenation of Pyridines and Quinolines Freifelder, Morris Advances in Catalysis https://doi.org/10.1016/S0360-0564(08)60340-5	book	January 1963
Hydrogenation of Some Pyridinealkanoic Acids Freifelder, Morris The Journal of Organic Chemistry, Vol. 28, Issue 2 https://doi.org/10.1021/jo01037a531	journal	February 1963
Kinins Collier, H. O. J. Scientific American, Vol. 207, Issue 2 https://doi.org/10.1038/scientificamerican0862-111	journal	August 1962
Antagonists of B ₂ bradykinin receptors Steranka, Larry R.; Farmer, Stephen G.; Burch, Ronald M. The FASEB Journal, Vol. 3, Issue 9 https://doi.org/10.1096/fasebj.3.9.2545496	journal	July 1989
Synthesis of Sydnones and Sydnone Imines Greco, Claude V.; Nyberg, Wayne H.; Cheng, C. C. Journal of Medicinal and Pharmaceutical Chemistry, Vol. 5, Issue 4 https://doi.org/10.1021/jm01239a022	journal	July 1962

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Related Subjects

polypeptide
amino
acid
replaced
n-benzylglycine
relates
polypeptides
useful
biological
activity
mammal
comprise
related
bradykinin
residues
specific
acids
chain
achiral
analogues
potent
agonist
antagonist
pharmacological
properties
depending
structure
preferred
-bradykinin
amino acid
amino acids
acid residues
acid residue
/530/

Title: Polypeptide having an amino acid replaced with N-benzylglycine

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References (8)

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