Automated two-dimensional interface for capillary gas chromatography

Patent · Tue Feb 20 00:00:00 EST 1996

OSTI ID:870301

Strunk, Michael R ^[1]; Bechtold, William E ^[1]

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1. Albuquerque, NM

A multidimensional gas chromatograph (GC) system having wide bore capillary and narrow bore capillary GC columns in series and having a novel system interface. Heart cuts from a high flow rate sample, separated by a wide bore GC column, are collected and directed to a narrow bore GC column with carrier gas injected at a lower flow compatible with a mass spectrometer. A bimodal six-way valve is connected with the wide bore GC column outlet and a bimodal four-way valve is connected with the narrow bore GC column inlet. A trapping and retaining circuit with a cold trap is connected with the six-way valve and a transfer circuit interconnects the two valves. The six-way valve is manipulated between first and second mode positions to collect analyte, and the four-way valve is manipulated between third and fourth mode positions to allow carrier gas to sweep analyte from a deactivated cold trap, through the transfer circuit, and then to the narrow bore GC capillary column for separation and subsequent analysis by a mass spectrometer. Rotary valves have substantially the same bore width as their associated columns to minimize flow irregularities and resulting sample peak deterioration. The rotary valves are heated separately from the GC columns to avoid temperature lag and resulting sample deterioration.

• Research Organization: LOVELACE BIOMED & ENV RES INST
• DOE Contract Number: AC04-76EV01013
• Assignee: Lovelace Biomedical & Environmental Research Institute, Inc. (Albuquerque, NM)
• Patent Number(s): US 5492555
• Application Number: 08/257,388
• OSTI ID: 870301
• Country of Publication: United States
• Language: English

Related Subjects

automated
two-dimensional
interface
capillary
gas
chromatography
multidimensional
chromatograph
gc
wide
bore
narrow
columns
series
novel
heart
cuts
flow
rate
sample
separated
column
collected
directed
carrier
injected
compatible
mass
spectrometer
bimodal
six-way
valve
connected
outlet
four-way
inlet
trapping
retaining
circuit
cold
trap
transfer
interconnects
valves
manipulated
mode
positions
collect
analyte
third
fourth
allow
sweep
deactivated
separation
subsequent
analysis
rotary
substantially
width
associated
minimize
irregularities
resulting
peak
deterioration
heated
separately
avoid
temperature
lag
rotary valves
narrow bore
subsequent analysis
capillary column
gas chromatography
cold trap
mass spectrometer
carrier gas
flow rate
gas chromatograph
transfer circuit
gas injected
capillary gas
bore capillary
rotary valve
capillary gc
/95/73/96/