Interim report on intrathoracic radiotherapy of human small-cell lung carcinoma in nude mice with Re-188-RC-160, a radiolabeled somatostatin analogue
- Univ. of Bonn (Germany). Dept. of Nuclear Medicine
- Oak Ridge National Lab., TN (United States). Health Sciences Research Div.
The purpose of this study was to evaluate the therapeutic efficacy of Re-188-RC-160 in experimental models of human small cell lung carcinomas which mimic the clinical presentation. In the experimental model, cells from the human small cell lung carcinoma cell line NCI-H69 cells were inoculated into the thoracic cavity of athymic mice and rats. Subsequently, the biodistribution of Re-188-RC-160 after injection into the pleural cavity, a radiolabeled somatostatin analogue, was monitored as was the effect on the subsequent growth of tumors. The results presented here, and which are a part of a larger series of studies, suggest that Re-188-RC-160 can be effectively used in this animal model to restrict the growth of small cell lung carcinoma in the thoracic cavity.
- Research Organization:
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- Sponsoring Organization:
- USDOE, Washington, DC (United States)
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 87003
- Report Number(s):
- CONF-9505232-2; ON: DE95014289; TRN: 95:017294
- Resource Relation:
- Conference: 5. Mediterranean symposium on nuclear medicine and radiopharmaceuticals - receptors, Athens (Greece), 23-28 May 1995; Other Information: PBD: [1995]
- Country of Publication:
- United States
- Language:
- English
Similar Records
Imaging of small-cell lung cancer xenografts with I-125, In-111, and Re-188 octreotides
High affinity binding of (/sup 125/I-Tyr/sup 11/)somatostatin-14 to human small cell lung carcinoma (NCI-H69)