Chamber for the optical manipulation of microscopic particles

Patent · Wed Jan 01 00:00:00 EST 1992

OSTI ID:868219

Buican, Tudor N ^[1]; Upham, Bryan D ^[1]

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1. Los Alamos, NM

A particle control chamber enables experiments to be carried out on biological cells and the like using a laser system to trap and manipulate the particles. A manipulation chamber provides a plurality of inlet and outlet ports for the particles and for fluids used to control or to contact the particles. A central manipulation area is optically accessible by the laser and includes first enlarged volumes for containing a selected number of particles for experimentation. A number of first enlarged volumes are connected by flow channels through second enlarged volumes. The second enlarged volumes act as bubble valves for controlling the interconnections between the first enlarged volumes. Electrode surfaces may be applied above the first enlarged volumes to enable experimentation using the application of electric fields within the first enlarged volumes. A variety of chemical and environmental conditions may be established within individual first enlarged volumes to enable experimental conditions for small scale cellular interactions.

• Research Organization: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
• DOE Contract Number: W-7405-ENG-36
• Assignee: Regents of University of California (Oakland, CA)
• Patent Number(s): US 5100627
• OSTI ID: 868219
• Country of Publication: United States
• Language: English

Related Subjects

chamber
optical
manipulation
microscopic
particles
particle
control
enables
experiments
carried
biological
cells
laser
trap
manipulate
provides
plurality
inlet
outlet
ports
fluids
contact
central
optically
accessible
enlarged
volumes
containing
selected
experimentation
connected
flow
channels
bubble
valves
controlling
interconnections
electrode
surfaces
applied
enable
application
electric
fields
variety
chemical
environmental
conditions
established
individual
experimental
scale
cellular
interactions
outlet ports
chamber provides
microscopic particles
flow channels
flow channel
electric field
electrode surface
electric fields
environmental conditions
biological cells
particle control
chamber provide
scale cell
electrode surfaces
chamber enable
biological cell
/422/356/359/