Precursors to radiopharmaceutical agents for tissue imaging

Patent · Fri Jan 01 00:00:00 EST 1988

OSTI ID:866689

Srivastava, Prem C ^[1]

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1. Oak Ridge, TN

A class of radiolabeled compounds to be used in tissue imaging that exhibits rapid brain uptake, good brain:blood radioactivity ratios, and long retention times. The imaging agents are more specifically radioiodinated aromatic amines attached to dihydropyridine carriers, that exhibit heart as well as brain specificity. In addition to the radiolabeled compounds, classes of compounds are also described that are used as precursors and intermediates in the preparation of the imaging agents.

• Research Organization: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
• DOE Contract Number: W-7405-ENG-26
• Assignee: United States of America as represented by Department of Energy (Washington, DC)
• Patent Number(s): US 4764598
• OSTI ID: 866689
• Country of Publication: United States
• Language: English

Related Subjects

precursors
radiopharmaceutical
agents
tissue
imaging
radiolabeled
compounds
exhibits
rapid
brain
uptake
blood
radioactivity
ratios
retention
times
specifically
radioiodinated
aromatic
amines
attached
dihydropyridine
carriers
exhibit
heart
specificity
addition
described
intermediates
preparation
aromatic amines
imaging agents
labeled compounds
retention time
imaging agent
tissue imaging
rapid brain
radiolabeled compound
aromatic amine
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