Carboxy, carboalkoxy and carbamile substituted isonitrile radionuclide complexes

Patent · Tue Apr 05 00:00:00 EDT 1988

OSTI ID:866559

Jones, Alun G ^[1]; Davison, Alan ^[2]; Kronauge, James ^[3]; Abrams, Michael J ^[4]

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1. Newton Centre, MA
2. Needham, MA
3. Cambridge, MA
4. Allston, MA

A coordination complex comprising a radionuclide selected from the class consisting of radioactive isotopes of Tc, Ru, Co, Pt and Re and an isonitrile ligand of the formula: (CNX)R, where X is a lower alkyl group having 1 to 4 carbon atoms, wherein R is selected from the group consisting of COOR.sup.1 and CONR.sup.2 R.sup.3 where R.sup.1 can be H, a pharmaceutically acceptable cation, or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, R.sup.2, and R.sup.3 can be H, or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, and R.sup.2 and R.sup.3 can be the same or different is disclosed. Kits that can be used to form these complexes are also disclosed.

• Research Organization: Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)
• DOE Contract Number: AC02-76EV04115
• Assignee: Massachusetts Institute of Technology (Cambridge, MA); President and Fellows of Harvard College (Cambridge, MA)
• Patent Number(s): US 4735793
• Application Number: 06/771,284
• OSTI ID: 866559
• Country of Publication: United States
• Language: English

Related Subjects

carboxy
carboalkoxy
carbamile
substituted
isonitrile
radionuclide
complexes
coordination
complex
comprising
selected
consisting
radioactive
isotopes
tc
ru
ligand
formula
cnx
alkyl
carbon
atoms
coor
conr
pharmaceutically
acceptable
cation
unsubstituted
disclosed
kits
form
unsubstituted alkyl
radionuclide complexes
radioactive isotope
isonitrile ligand
carbon atoms
carbon atom
pharmaceutically acceptable
isonitrile radionuclide
radioactive isotopes
coordination complex
radionuclide selected
substituted isonitrile
complex comprising
substituted alkyl
carbamile substituted
/424/999/987/