Nose-only exposure system

Patent · Fri Jan 01 00:00:00 EST 1988

OSTI ID:866478

Cannon, William C ^[1]; Bass, Edward W ^[2]

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1. Richland, WA
2. Kennewick, WA

An exposure system for supplying a gaseous material, i.e. an aerosol, gas or a vapor, directly to the noses of experimental animals includes concentric vertical inner and outer manifolds. The outer manifold connects with the necks of a large number of bottles in which the animals are confined with their noses adjacent the bottle necks. Readily detachable small tubes communicate with the inner manifold and extend to the necks of the bottles. The upper end of the outer manifold and the lower end of the inner manifold are closed. Gaseous material is supplied to the upper end of the inner manifold, flows through the small tubes to points adjacent the noses of the individual animals, then is drawn out through the bottom of the outer manifold. The bottles are readily removable and the device can be disassembled, e.g., for cleaning, by removing the bottles, removing the small tubes, and lifting the inner manifold from the outer manifold. The bottles are supported by engagement of their necks with the outer manifold supplemented, if additional support is required, by individual wire cradles. The outer ends of the bottles are closed by plugs, through which pass metal tubes which receive the tails of the animals (usually rodents) and which serve to dissipate body heat. The entire device is mounted for rotation on turntable bearings.

• Research Organization: Battelle Memorial Institute, Columbus, OH (United States)
• DOE Contract Number: AC06-76RL01830
• Assignee: Battelle Memorial Institute (Columbus, OH)
• Patent Number(s): US 4721060
• OSTI ID: 866478
• Country of Publication: United States
• Language: English

Related Subjects

nose-only
exposure
supplying
gaseous
material
aerosol
gas
vapor
directly
noses
experimental
animals
concentric
vertical
inner
outer
manifolds
manifold
connects
necks
bottles
confined
adjacent
bottle
readily
detachable
tubes
communicate
extend
upper
closed
supplied
flows
individual
drawn
bottom
removable
device
disassembled
cleaning
removing
lifting
supported
engagement
supplemented
additional
support
required
wire
cradles
plugs
pass
metal
receive
tails
rodents
serve
dissipate
heat
entire
mounted
rotation
turntable
bearings
outer manifold
gaseous material
metal tube
readily removable
metal tubes
experimental animals
nose-only exposure
outer manifolds
entire device
manifold connects
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