.sup.18 F-4-Fluoroantipyrine

Patent · Tue Mar 13 00:00:00 EST 1984

OSTI ID:864913

Shiue, Chyng-Yann ^[1]; Wolf, Alfred P ^[2]

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1. Wading River, NY
2. Setauket, NY

The novel radioactive compound .sup.18 F-4-fluoroantipyrine having high specific activity which can be used in nuclear medicine in diagnostic applications, prepared by the direct fluorination of antipyrine in acetic acid with radioactive fluorine at room temperature and purifying said radioactive compound by means of gel chromatography with ethyl acetate as eluent is disclosed. The non-radioactive 4-fluoroantipyrine can also be prepared by the direct fluorination of antipyrine in acetic acid with molecular fluorine at room temperature and purified by means of gel chromotography with ethyl acetate eluent.

• Research Organization: Associated Universities, Inc., Upton, NY (United States)
• DOE Contract Number: AC02-76CH00016
• Assignee: United States of America as represented by United States (Washington, DC)
• Patent Number(s): US 4436717
• Application Number: 06/268,422
• OSTI ID: 864913
• Country of Publication: United States
• Language: English

Related Subjects

18
f-4-fluoroantipyrine
novel
radioactive
compound
specific
activity
nuclear
medicine
diagnostic
applications
prepared
direct
fluorination
antipyrine
acetic
acid
fluorine
temperature
purifying
means
chromatography
ethyl
acetate
eluent
disclosed
non-radioactive
4-fluoroantipyrine
molecular
purified
chromotography
acetic acid
nuclear medicine
ethyl acetate
specific activity
radioactive compound
active compound
direct fluorination
novel radioactive
diagnostic applications
/424/376/999/