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Title: Chemical Force Microscopy: Probing Chemical Origin of Interfacial Forces and Adhesion

Journal Article · · Journal of Adhesion Science and Technology

Experimental methods of measuring intermolecular interactions have had several recent developments which have improved our understanding of chemical forces. First, they allowed direct exploration of the role that different functionalities, solvents and environmental variables play in shaping the strength of intermolecular interactions. Chemical force microscopy approach, in particular, became an extremely effective tool for exploring the contributions of each of these factors. Second, CFM studies clearly debunked the naive notion that intermolecular interaction strength is determined only by the nature of the interacting groups. These studies showed that the interaction strength between two chemical species must always considered in context of the environment surrounding these species. Third, CFM studies highlighted the critical role solvent plays in shaping intermolecular interactions in condensed phases. Emerging kinetic view of the intermolecular interactions introduced a completely new paradigm for understanding these interactions. Kinetic modeling showed that the measured interactions strength depends not only on the energy landscape of the system, but also on the loading history prior to the bond break-up. This new paradigm refocused our attention to the energy landscape as a fundamental characteristic of the interaction. Moreover, dynamic force spectroscopy, derived from kinetic models, allowed direct characterization of the geometry of the potential energy barrier, while some other methods attempt to probe the equilibrium energy landscape directly. Further investigations of the interactions in different systems, especially interactions between biomolecules, will uncover many interesting characteristics of intermolecular potentials. These studies have the potential to reveal, for the first time, a true picture of the energy landscapes of adhesion processes in complex chemical and biological systems.

Research Organization:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
W-7405-ENG-48
OSTI ID:
862388
Report Number(s):
UCRL-JRNL-211059; TRN: US200602%%499
Journal Information:
Journal of Adhesion Science and Technology, Vol. 19, Issue 3-5
Country of Publication:
United States
Language:
English

References (95)

A Double-Scale Equation for Correlating Enthalpies of Lewis Acid-Base Interactions journal August 1965
Surface properties of oxidized LDPE by scanning force microscopy with chemically modified probes journal October 1998
Chemical Effects on the Adhesion and Friction between Alkanethiol Monolayers:  Molecular Dynamics Simulations journal October 2003
Effect of contact deformations on the adhesion of particles journal November 1975
Role of Surface Perfection in Chemical Force Microscopy journal May 1998
The general theory of van der Waals forces journal April 1961
Demonstration of High-Resolution Capability of Chemical Force Titration via Study of Acid/Base Properties of a Patterned Self-Assembled Monolayer journal January 2000
Analytical instrumentation based on force measurements: combinatorial atomic force microscopy journal October 2003
Molecular Resolution Imaging and Friction Anisotropy of Highly Oriented Polyethylene and Poly(tetrafluoroethylene) by Scanning Force Microscopy with Chemically Modified Probes journal October 1997
Determination of the Ionization State of 11-Thioundecyl-1-phosphonic Acid in Self-Assembled Monolayers by Chemical Force Microscopy journal May 2000
Direct Measurement of Surface Forces between Monolayers of Anchored Poly(L-glutamic acid) journal February 1995
An Adhesion Map for the Contact of Elastic Spheres journal August 1997
Surface Characterization of Oxyfluorinated Isotactic Polypropylene Films:  Scanning Force Microscopy with Chemically Modified Probes and Contact Angle Measurements journal June 1998
Chemical force microscopy of microcontact-printed self-assembled monolayers by pulsed-force-mode atomic force microscopy journal February 2000
Determination of Energy Barriers for Intermolecular Interactions by Variable Temperature Dynamic Force Spectroscopy journal March 2003
The interfacial-force microscope journal March 1992
The general theory of molecular forces journal January 1937
pH-Dependent Force Spectroscopy of Tri(ethylene Glycol)- and Methyl-Terminated Self-Assembled Monolayers Adsorbed on Gold journal October 2002
Nonequilibrium Equality for Free Energy Differences journal April 1997
Self-Assembly in Natural and Unnatural Systems journal June 1996
Friction and adhesion of mixed self-assembled monolayers studied by chemical force microscopy journal January 1999
Chemical force microscopy: applications in surface characterisation of natural hydroxyapatite journal March 2003
Covalently functionalized nanotubes as nanometre- sized probes in chemistry and biology journal July 1998
Stretching and breaking duplex DNA by chemical force microscopy journal July 1997
Direct measurement of drug–enzyme interactions by atomic force microscopy; dihydrofolate reductase and methotrexate journal January 2002
Probing Intermolecular Forces and Potentials with Magnetic Feedback Chemical Force Microscopy journal October 2000
Pull-off forces measured between hexadecanethiol self-assembled monolayers in air using an atomic force microscope: analysis of surface free energy journal January 2002
Chemical Force Microscopy: Exploiting Chemically-Modified Tips To Quantify Adhesion, Friction, and Functional Group Distributions in Molecular Assemblies journal August 1995
Direct mechanical measurement of interatomic potentials journal November 1996
Contact Mechanics Modeling of Pull-Off Measurements:  Effect of Solvent, Probe Radius, and Chemical Binding Probability on the Detection of Single-Bond Rupture Forces by Atomic Force Microscopy journal July 2002
Single-Molecule Investigations of RNA Dissociation journal June 2004
Dynamic Simulations of Adhesion and Friction in Chemical Force Microscopy journal October 2002
Theoretical studies on force titration of amino-group-terminated self-assembled monolayers journal October 1998
Force Titrations and Ionization State Sensitive Imaging of Functional Groups in Aqueous Solutions by Chemical Force Microscopy journal February 1997
Structural and functional imaging with carbon nanotube AFM probes journal January 2001
Covalently-Functionalized Single-Walled Carbon Nanotube Probe Tips for Chemical Force Microscopy journal August 1998
Surface Energy and the Contact of Elastic Solids
  • Johnson, K. L.; Kendall, K.; Roberts, A. D.
  • Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, Vol. 324, Issue 1558 https://doi.org/10.1098/rspa.1971.0141
journal September 1971
Observation of Silver and Hydrogen Ion Binding to Self-Assembled Monolayers Using Chemically Modified AFM Tips journal April 1999
Solvent Exclusion and Chemical Contrast in Scanning Force Microscopy journal January 1996
Influence of Molecular Arrangement in Self-Assembled Monolayers on Adhesion Forces Measured by Chemical Force Microscopy journal October 2003
Functional Group Imaging by Chemical Force Microscopy journal September 1994
A General Equation for Fitting Contact Area and Friction vs Load Measurements journal March 1999
Interfacial Lifshitz-van der Waals and polar interactions in macroscopic systems journal September 1988
Introductory Lecture Energy landscapes of biomolecular adhesion and receptor anchoring at interfaces explored with dynamic force spectroscopy journal January 1999
Equilibrium Information from Nonequilibrium Measurements in an Experimental Test of Jarzynski's Equality journal June 2002
Alternative Method for Fabricating Chemically Functionalized AFM Tips:  Silane Modification of HF-Treated Si 3 N 4 Probes journal May 2004
Force-induced melting of a short DNA double helix journal April 2001
Atomic Force Microscopy of Elastomers: Morphology, Distribution of Filler Particles, and Adhesion Using Chemically Modified Tips journal November 1999
Chemical reactivity and the concept of charge- and frontier-controlled reactions journal January 1968
Interpretation of adhesion force between self-assembled monolayers measured by chemical force microscopy journal March 2003
On the influence of molecular forces on the deformation of an elastic sphere and its sticking to a rigid plane journal September 1980
Rupture of Hydrophobic Microcontacts in Water:  Correlation of Pull-Off Force with AFM Tip Radius journal July 2000
Dynamic force spectroscopy of single DNA molecules journal September 1999
Modification of Silicon AFM Cantilever Tips with an Oligo(ethylene glycol) Derivative for Resisting Proteins and Maintaining a Small Tip Size for High-Resolution Imaging journal June 2003
A study of topographic effects on chemical force microscopy using adhesive force mapping journal October 2003
Chemical Force Microscopy of Mixed Self-Assembled Monolayers of Alkanethiols on Gold:  Evidence for Phase Separation journal May 2004
Friction force microscopy of self-assembled monolayers: probing molecular organisation at the nanometre scale journal March 2003
Complex Chemical Force Titration Behavior of Amine-Terminated Self-Assembled Monolayers journal February 2001
Chemical Force Microscopy journal August 1997
Surface derivatization of nanoscale tungsten probes for interfacial force microscopy
  • Graham, J. F.; Griffiths, K.; Kovar, M.
  • Journal of Vacuum Science & Technology A: Vacuum, Surfaces, and Films, Vol. 17, Issue 4 https://doi.org/10.1116/1.581754
journal July 1999
Hidden complexity in the mechanical properties of titin journal March 2003
Microparticle adhesion studies by atomic force microscopy journal January 2002
Chemical Force Titration of Conjugated Pyridyl Group-Terminated Self-Assembled Monolayers
  • He, Hui-Xin; Zhang, Hua; Wang, Yin-Chuan
  • Molecular Crystals and Liquid Crystals Science and Technology. Section A. Molecular Crystals and Liquid Crystals, Vol. 337, Issue 1 https://doi.org/10.1080/10587259908023437
journal November 1999
Adhesion of spheres: The JKR-DMT transition using a dugdale model journal April 1992
Chemical Force Spectroscopy and Imaging journal January 2001
Atomistic Molecular Dynamics Simulations of Chemical Force Microscopy journal June 2003
Dynamic strength of molecular adhesion bonds journal April 1997
The Effect of Electrolyte Concentration on the Chemical Force Titration Behavior of ω-Functionalized SAMs:  Evidence for the Formation of Strong Ionic Hydrogen Bonds journal September 2000
Entropic Barriers in Nanoscale Adhesion Studied by Variable Temperature Chemical Force Microscopy journal February 2003
Nanoscale Hydrophobic Recovery: A Chemical Force Microscopy Study of UV/Ozone-Treated Cross-Linked Poly(dimethylsiloxane) journal February 2004
Reaction-rate theory: fifty years after Kramers journal April 1990
Chemical Force Microscopy Study of Adhesion and Friction between Surfaces Functionalized with Self-Assembled Monolayers and Immersed in Solvents journal May 1999
Distributions of Functional Groups in Plasma Polymerized Allylamine Films by Scanning Force Microscopy Using Functionalized Probe Tips journal December 2000
Atomic Force Microscope journal March 1986
Force Titration of a Carboxylic Acid Terminated Self-Assembled Monolayer Using Chemical Force Microscopy
  • He, H. X.; Li, C. Z.; Song, J. Q.
  • Molecular Crystals and Liquid Crystals Science and Technology. Section A. Molecular Crystals and Liquid Crystals, Vol. 294, Issue 1 https://doi.org/10.1080/10587259708032258
journal March 1997
Influence of Architecture on the Kinetic Stability of Molecular Assemblies journal February 2004
A novel cleaning method of gold-coated atomic force microscope tips for their chemical modification journal February 2000
Surfaces, Interfaces, and Colloids book January 1999
Study on the surface dissociation properties of 6-(10-mercaptodecaoxyl)quinoline self-assembled monolayer on gold by chemical force titration journal December 1999
Chemical Force Spectroscopy in Heterogeneous Systems:  Intermolecular Interactions Involving Epoxy Polymer, Mixed Monolayers, and Polar Solvents journal September 2002
Models for the specific adhesion of cells to cells journal May 1978
Friction force microscopy using silicon cantilevers covered with organic monolayers via silicon–carbon covalent bonds journal July 2003
Modification of Silicon Nitride Tips with Trichlorosilane Self-Assembled Monolayers (SAMs) for Chemical Force Microscopy journal August 1997
Analysis of atomic force microscope pull-off forces for gold surfaces portraying nanoscale roughness and specific chemical functionality journal January 2004
Adhesion, Friction, and Mechanical Properties of Functionalized Alkanethiol Self-Assembled Monolayers journal July 2002
Force titration of amino group-terminated self-assembled monolayers of 4-aminothiophenol on gold using chemical force microscopy journal August 1998
Scratching the Surface:  Fundamental Investigations of Tribology with Atomic Force Microscopy journal June 1997
Chemical Force Microscopy Investigation of Phosphate Adsorption on the Surfaces of Iron(III) Oxyhydroxide Particles journal October 2002
The effect of liquid-induced adhesion changes on the interfacial shear strength between self-assembled monolayers journal January 2003
Acid−Base Properties and the Chemical Imaging of Surface-Bound Functional Groups Studied with Scanning Force Microscopy journal November 1997
Energy landscapes of receptor–ligand bonds explored with dynamic force spectroscopy journal January 1999
Force titration of amino group-terminated self-assembled monolayers using chemical force microscopy journal March 1998
Towards mapping of functional group distributions in functional polymers by AFM force titration measurements journal January 2000
Brownian Force Profile Reconstruction of Interfacial 1-Nonanol Solvent Structure journal December 2004
Kinetics and Domain Formation in Surface Reactions by Inverted Chemical Force Microscopy and FTIR Spectroscopy book December 2000