Use of specifically {sup 15}N-labeled histidine to study structures and mechanisms within the active sites of serine proteinases
Conference
·
OSTI ID:83372
- Tufts Univ. School of Medicine, Boston, MA (United States)
The current emphasis in biological NMR work is on determining structures of biological macromolecules in solution. This emphasis is appropriate because NMR is the only technique capable of providing high-resolution structures that are comparable to those of x-ray crystallography for molecules in solution. This structural knowledge is immensely valuable and is needed in many areas of investigation. However, as valuable as such structural knowledge is, it never provides all the answers; a structure often reveals more questions than answers.
- Research Organization:
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- OSTI ID:
- 83372
- Report Number(s):
- LA-12893-C; CONF-9403228-; ON: DE95012795; TRN: 95:004732-0003
- Resource Relation:
- Conference: Stable isotope applications in biomolecular structure and mechanisms, Santa Fe, NM (United States), 27-31 Mar 1994; Other Information: PBD: Dec 1994; Related Information: Is Part Of Stable isotope applications in biomolecular structure and mechanisms. A meeting to bring together producers and users of stable-isotope-labeled compounds to assess current and future needs; Trewhella, J.; Cross, T.A.; Unkefer, C.J. [eds.]; PB: 382 p.
- Country of Publication:
- United States
- Language:
- English
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