Lesion detection and quantitation of positron emission mammography
A Positron Emission Mammography (PEM) scanner dedicated to breast imaging is being developed at our laboratory. We have developed a list mode likelihood reconstruction algorithm for this scanner. Here we theoretically study the lesion detection and quantitation. The lesion detectability is studied theoretically using computer observers. We found that for the zero-order quadratic prior, the region of interest observer can achieve the performance of the prewhitening observer with a properly selected smoothing parameter. We also study the lesion quantitation using the test statistic of the region of interest observer. The theoretical expressions for the bias, variance, and ensemble mean squared error of the quantitation are derived. Computer simulations show that the theoretical predictions are in good agreement with the Monte Carlo results for both lesion detection and quantitation.
- Research Organization:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Sponsoring Organization:
- USDOE Director, Office of Science, Office of Biological and Environmental Research, Medical Sciences Division; U.S. Department of Health and Human Services, Grant P01 HL25840, National Cancer Institute, Grant R01 CA 59794 (US)
- DOE Contract Number:
- AC03-76SF00098
- OSTI ID:
- 815475
- Report Number(s):
- LBNL-49397; R&D Project: 860530; TRN: US0304616
- Resource Relation:
- Conference: IEEE Nuclear Science Symposium and Medical Imaging Conference, San Diego, CA (US), 11/10/2001; Other Information: PBD: 1 Dec 2001
- Country of Publication:
- United States
- Language:
- English
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