Intracellular localization of titanium dioxide-biomolecule nanocomposites.
Emerging areas of nanotechnology hold the promise of overcoming the limitations of existing technology for intracellular manipulation. These new developments include the creation of nanocomposites that can be introduced into the cells, targeted to specific subcellular sites, and subsequently used as platforms for initiation of intracellular processes dependent on or aided by locally high concentrations of specific molecules delivered as components of the nanocomposites. Nanocomposites that combine functional properties of biomolecules with the functional properties of inorganic components could provide new tools for biology, medicine, chemistry and material sciences. Here we describe how we introduced TiO{sub 2}-DNA nanocomposites into cells, and localized titanium in the cells by mapping the Ti K{alpha} X-ray fluorescence induced at the 2-ID-E microprobe of the SRI-CAT at the Advanced Photon Source at Argonne National Laboratory.
- Research Organization:
- Argonne National Lab., IL (US)
- Sponsoring Organization:
- US Department of Energy (US)
- DOE Contract Number:
- W-31-109-ENG-38
- OSTI ID:
- 803882
- Report Number(s):
- ANL/XFD/CP-108965; TRN: US0300331
- Resource Relation:
- Journal Volume: 104; Conference: 7th International Conference on X-ray Microscope (XRM 2002), Grenoble (FR), 07/29/2002--08/02/2002; Other Information: PBD: 30 Oct 2002
- Country of Publication:
- United States
- Language:
- English
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