DNA Repair Enzyme-Liposomes: Human Skin Cancer Prevention

Technical Report · Thu Sep 16 00:00:00 EDT 1999

DOI:https://doi.org/10.2172/770453· OSTI ID:770453

This project centered on responses of human cells to ultraviolet radiation at the fundamental and practical levels. At the fundamental levels, the relation of DNA damage to cell signaling events such as cytokine induction were studied; paths in human cells for dealing with DNA damage were studied at the nucleotide sequence level. At the practical, new, effective and inexpensive UVB filters were devised and characterized; further, to make low frequency DNA damage quantitation more generally available, a commercially-obtainable electrophoretic mode (Contour Clamped Homogeneous Electric Field) was tested and determined to give good dispersions of high molecular length DNAs.

• Research Organization: Brookhaven National Lab. (BNL), Upton, NY (United States)
• Sponsoring Organization: USDOE Office of Science (SC)
• DOE Contract Number: AC02-98CH10886
• OSTI ID: 770453
• Report Number(s): BNL-83313-1999; CRADA # BNL-C-95-04
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
Progress Report
DNA Repair
Enzymes
Liposomes
Skin Diseases
Neoplasms