The theoretical basis and clinical methodology for stereotactic interstitial brain tumor irradiation using iododeoxyuridine as a radiation sensitizer and samarium-145 as a brachytherapy source

Conference · Sun Jan 01 00:00:00 EST 1989

OSTI ID:7192249

Goodman, J H; Gahbauer, R A; Kanellitsas, C; Clendenon, N R ^[1]; Laster, B H; Fairchild, R G ^[2]

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1. Ohio State Univ., Columbus, OH (USA)
2. Brookhaven National Lab., Upton, NY (USA)

High grade astrocytomas have proven resistant to all conventional therapy. A technique to produce radiation enhancement during interstitial brain tumor irradiation by using a radiation sensitizer (IdUrd) and by stimulation of Auger electron cascades through absorption of low energy photons in iodine (Photon activation) is described. Clinical studies using IdUrd, {sup 192}Ir as a brachytherapy source, and external radiation have produced promising results. Substituting samarium-145 for {sup 192}Ir in this protocol is expected to produce enhanced results. 15 refs.

• Research Organization: Brookhaven National Lab., Upton, NY (USA)
• Sponsoring Organization: DOE/ER
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 7192249
• Report Number(s): BNL-44560; CONF-8910409-1; ON: DE90011518; TRN: 90-026996
• Resource Relation: Conference: 10. meeting of the world society for stereotactic and functional neurosurgery, Maebashi (Japan), 2-5 Oct 1989
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ASTROCYTOMAS
RADIOTHERAPY
BRAIN
NEOPLASMS
IODODEOXYURIDINE
THERAPEUTIC USES
IRIDIUM 192
EXTERNAL IRRADIATION
SAMARIUM 145
ABSORPTION
AUGER EFFECT
DIAGNOSTIC TECHNIQUES
DNA
DOSIMETRY
DRUGS
PHOTONS
RADIATION DOSES
RADIATION SOURCES
RADIOSENSITIVITY
SENSITIZERS
TUMOR CELLS
ANIMAL CELLS
ANTIMETABOLITES
AZINES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CENTRAL NERVOUS SYSTEM
DAYS LIVING RADIOISOTOPES
DISEASES
DOSES
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTARY PARTICLES
EVEN-ODD NUCLEI
GLIOMAS
HEAVY NUCLEI
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IODOURACILS
IRIDIUM ISOTOPES
IRRADIATION
ISOMERIC TRANSITION
ISOTOPES
MASSLESS PARTICLES
MEDICINE
NERVOUS SYSTEM
NUCLEAR MEDICINE
NUCLEI
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIMIDINES
RADIOISOTOPES
RADIOLOGY
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
REAGENTS
RIBOSIDES
SAMARIUM ISOTOPES
THERAPY
URACILS
USES
550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)
550603 - Medicine- External Radiation in Therapy- (1980-)