Clinical results of stereotactic helium-ion radiosurgery of the pituitary gland at Lawrence Berkeley Laboratory

Conference · Fri Dec 01 00:00:00 EST 1989

OSTI ID:7146296

Levy, R P; Fabrikant, J I; Lyman, J T; Frankel, K A; Phillips, M H; Lawrence, J H; Tobias, C A

The first therapeutic clinical trial using accelerated heavy-charged particles in humans was performed for the treatment of various endocrine and metabolic disorders of the pituitary gland, and as suppressive therapy for adenohypophyseal hormone-responsive carcinomas and diabetic retinopathy. Since then, over 800 patients have received stereotactically-directed plateau-beam heavy-charged particle pituitary irradiation at this institution. In acromegaly, Cushing's disease, Nelson's syndrome and prolactin-secreting tumors, the therapeutic goal in the 433 patients treated has been to destroy or inhibit the growth of the pituitary tumor and control hormonal hypersecretion, while preserving a functional rim of tissue with normal hormone-secreting capacity, and minimizing neurologic injury. An additional group of 34 patients was treated for nonsecreting chromophobe adenomas. This paper discusses the methods and results of these treatments. 11 refs.

• Research Organization: Lawrence Berkeley Lab., CA (USA)
• Sponsoring Organization: DOE/ER
• DOE Contract Number: AC03-76SF00098
• OSTI ID: 7146296
• Report Number(s): LBL-28253; CONF-8905227-6; ON: DE90008467; TRN: 90-008738
• Resource Relation: Conference: International conference on radiosurgery a neurosurgical approach to intracranial lesions, Charlottesville, VA (USA), 1-5 May 1989
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CHARGED PARTICLES
THERAPEUTIC USES
ENDOCRINE DISEASES
THERAPY
METABOLIC DISEASES
PITUITARY GLAND
RADIOTHERAPY
ACROMEGALY
CARCINOMAS
CUSHING SYNDROME
HELIUM IONS
INTERNAL IRRADIATION
LAWRENCE BERKELEY LABORATORY
MAN
MINIMIZATION
NEOPLASMS
NEUROLOGY
PITUITARY HORMONES
SURGERY
ANIMALS
BODY
DISEASES
ENDOCRINE GLANDS
GLANDS
HORMONES
IONS
IRRADIATION
MAMMALS
MEDICINE
NATIONAL ORGANIZATIONS
NUCLEAR MEDICINE
ORGANS
PEPTIDE HORMONES
PRIMATES
RADIOLOGY
US AEC
US DOE
US ERDA
US ORGANIZATIONS
USES
VERTEBRATES
550603* - Medicine- External Radiation in Therapy- (1980-)